马昔腾坦治疗重度指端溃疡
Macitentan in the treatment of severe digital ulcers.
作者信息
Gonçalves Tatiana, Santos Lèlita
机构信息
Internal Medicine Service, Coimbra Hospital and University Centre, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
出版信息
BMJ Case Rep. 2019 Aug 12;12(8):e228295. doi: 10.1136/bcr-2018-228295.
Abstract
Digital ulcers are one of the earliest and most disabling manifestations of systemic sclerosis (SSc). We report the clinical case of a female patient with SSc and severe digital ulcers, recurrent and refractory to the classic treatments to whom it was prescribed off-label macitentan with complete resolution of the condition.
摘要
指端溃疡是系统性硬化症（SSc）最早出现且最具致残性的表现之一。我们报告了一例患有SSc且伴有严重指端溃疡的女性患者的临床病例，该患者的溃疡反复发作且对传统治疗无效，我们为其超说明书使用马昔腾坦进行治疗，最终病情完全缓解。
相似文献
1
Macitentan in the treatment of severe digital ulcers.马昔腾坦治疗重度指端溃疡
BMJ Case Rep. 2019 Aug 12;12(8):e228295. doi: 10.1136/bcr-2018-228295.
2
Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis: DUAL-1 and DUAL-2 Randomized Clinical Trials.马昔腾坦治疗系统性硬化症患者新发缺血性指端溃疡的效果：DUAL-1 和 DUAL-2 随机临床试验。
JAMA. 2016 May 10;315(18):1975-88. doi: 10.1001/jama.2016.5258.
3
Bosentan as a rescue therapy in scleroderma refractory digital ulcers.波生坦作为硬皮病难治性指端溃疡的挽救治疗方法。
Arch Dermatol. 2007 Jan;143(1):125-6. doi: 10.1001/archderm.143.1.125.
4
Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene.波生坦显著减轻弥漫性皮肤系统性硬皮病伴多发性指端溃疡和坏疽患者的大血管受累。
Mod Rheumatol. 2011 Oct;21(5):548-52. doi: 10.1007/s10165-011-0436-5. Epub 2011 Mar 10.
5
Connective tissue diseases: Treatment of digital ulcers in systemic sclerosis.结缔组织病：系统性硬化症中手指溃疡的治疗
Nat Rev Rheumatol. 2011 Jan;7(1):5-6. doi: 10.1038/nrrheum.2010.207. Epub 2010 Nov 30.
6
Bosentan for digital ulcers in patients with systemic sclerosis.波生坦治疗系统性硬化症患者的手指溃疡。
J Dermatol. 2012 Jan;39(1):48-51. doi: 10.1111/j.1346-8138.2011.01299.x. Epub 2011 Sep 28.
7
[Digital ulcers in systemic sclerosis].[系统性硬化症中的指端溃疡]
Presse Med. 2008 Apr;37(4 Pt 2):735-6. doi: 10.1016/j.lpm.2008.01.002. Epub 2008 Feb 6.
8
Successful treatment of systemic sclerosis-related digital ulcers and sarcoidosis with endothelin receptor antagonist (bosentan) therapy.用内皮素受体拮抗剂（波生坦）治疗系统性硬化症相关指端溃疡和结节病取得成功。
Br J Dermatol. 2006 May;154(5):1000-2. doi: 10.1111/j.1365-2133.2006.07194.x.
9
[Digital ulcers in systemic sclerosis: use of endotheline antagonists].
Acta Med Port. 2011 Sep-Oct;24(5):837-42. Epub 2011 Dec 29.
10
Bosentan for digital ulcers in patients with systemic sclerosis: a prospective 3-year followup study.波生坦治疗系统性硬化症患者指端溃疡：一项为期3年的前瞻性随访研究。
J Rheumatol. 2009 Jul;36(7):1550-2. doi: 10.3899/jrheum.080992.
引用本文的文献
1
Macitentan for the Treatment of Refractory Digital Ulcers in Patients With Connective Tissue Diseases.马昔腾坦用于治疗结缔组织病患者的难治性指端溃疡
Cureus. 2023 Apr 29;15(4):e38303. doi: 10.7759/cureus.38303. eCollection 2023 Apr.
2
Treatment of digital ulcers in systemic sclerosis: recent developments and future perspectives.系统性硬化症中手指溃疡的治疗：最新进展与未来展望。
Clin Rheumatol. 2023 Oct;42(10):2589-2599. doi: 10.1007/s10067-023-06511-0. Epub 2023 Feb 27.
本文引用的文献
1
[Pharmacological and clinical profile of a novel dual endothelin receptor antagonist, macitentan (Opsumit)].新型双重内皮素受体拮抗剂马昔腾坦（Opsumit）的药理及临床概况
Nihon Yakurigaku Zasshi. 2017;149(1):49-58. doi: 10.1254/fpj.149.49.
2
Swift and Complete Healing of Digital Ulcers after Macitentan Treatment.马昔腾坦治疗后指端溃疡迅速完全愈合。
Case Rep Rheumatol. 2016;2016:1718309. doi: 10.1155/2016/1718309. Epub 2016 Nov 22.
3
Is macitentan not a treatment option for digital ulcers in systemic sclerosis?马昔腾坦难道不是系统性硬化症中治疗指端溃疡的一种选择吗？
Ann Transl Med. 2016 Oct;4(Suppl 1):S6. doi: 10.21037/atm.2016.08.67.
4
Effect of Macitentan on the Development of New Ischemic Digital Ulcers in Patients With Systemic Sclerosis: DUAL-1 and DUAL-2 Randomized Clinical Trials.马昔腾坦治疗系统性硬化症患者新发缺血性指端溃疡的效果：DUAL-1 和 DUAL-2 随机临床试验。
JAMA. 2016 May 10;315(18):1975-88. doi: 10.1001/jama.2016.5258.
5
Ischemic digital ulcers affect hand disability and pain in systemic sclerosis.缺血性指端溃疡影响系统性硬化症患者的手部功能及疼痛。
J Rheumatol. 2014 Jul;41(7):1317-23. doi: 10.3899/jrheum.130900. Epub 2014 Jun 15.
6
[Hand involvement in systemic sclerosis].[手部受累于系统性硬化症]
Presse Med. 2013 Dec;42(12):1616-26. doi: 10.1016/j.lpm.2013.10.003. Epub 2013 Nov 21.
7
2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative.2013 年系统性硬化症分类标准：美国风湿病学会/欧洲抗风湿病联盟合作倡议。
Ann Rheum Dis. 2013 Nov;72(11):1747-55. doi: 10.1136/annrheumdis-2013-204424.
8
Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial.波生坦治疗系统性硬化症相关的手指溃疡：RAPIDS-2 随机、双盲、安慰剂对照试验结果。
Ann Rheum Dis. 2011 Jan;70(1):32-8. doi: 10.1136/ard.2010.130658. Epub 2010 Aug 30.
9
Digital ulcers in scleroderma: staging, characteristics and sub-setting through observation of 1614 digital lesions.硬皮病的指端溃疡：通过观察 1614 个指端病变进行分期、特征分析和亚组划分。
Rheumatology (Oxford). 2010 Jul;49(7):1374-82. doi: 10.1093/rheumatology/keq097. Epub 2010 Apr 16.
Zotero 插件