Gonçalves Tatiana, Santos Lèlita
Internal Medicine Service, Coimbra Hospital and University Centre, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
BMJ Case Rep. 2019 Aug 12;12(8):e228295. doi: 10.1136/bcr-2018-228295.
Digital ulcers are one of the earliest and most disabling manifestations of systemic sclerosis (SSc). We report the clinical case of a female patient with SSc and severe digital ulcers, recurrent and refractory to the classic treatments to whom it was prescribed off-label macitentan with complete resolution of the condition.
指端溃疡是系统性硬化症（SSc）最早出现且最具致残性的表现之一。我们报告了一例患有SSc且伴有严重指端溃疡的女性患者的临床病例，该患者的溃疡反复发作且对传统治疗无效，我们为其超说明书使用马昔腾坦进行治疗，最终病情完全缓解。
