Poulsen S, Larson R H, Senning R S
Scand J Dent Res. 1978 Jul;86(4):231-6. doi: 10.1111/j.1600-0722.1978.tb00623.x.
Plaque formation and caries development were studied in 0-M rats fed Diet 2000 and infected with S. mutans 6715 and fecal flora from older caries-active rats. Merck dextranase, Beckman dextranase or Beckman glucanase 447 were administered singly or in combination to groups of 12 rats either as an addition to the diet or as a "mouthwash" twice daily, 5 per week. All enzymes studied were associated with significant inhibition of both plaque formation and caries development, especially on the buccal and lingual surfaces.
对喂食2000号饮食并感染变形链球菌6715和来自患龋活跃的老年大鼠粪便菌群的无特定病原体（SPF）大鼠的菌斑形成和龋齿发展进行了研究。将默克葡聚糖酶、贝克曼葡聚糖酶或贝克曼葡聚糖酶447单独或联合给予每组12只大鼠，作为饮食添加物或作为“漱口水”，每天两次，每周5次。所有研究的酶都与显著抑制菌斑形成和龋齿发展有关，尤其是在颊面和舌面。
