Willmott Ashley G B, Bliss Alex, Simpson William H, Tocker Steve M, Cottingham Rowland, Maxwell Neil S
a Centre for Sport and Exercise Science and Medicine (SeSAME), Environmental Extremes Laboratory , University of Brighton , UK.
b BodyChillz, The Beehive , UK.
Int J Occup Saf Ergon. 2018 Mar;24(1):118-128. doi: 10.1080/10803548.2016.1273640. Epub 2017 Feb 2.
Cooling of the body is used to treat hyperthermic individuals with heatstroke or to depress core temperature below normal for neuroprotection. A novel, chemically activated, unpowered cooling device, CAERvest®, was investigated for safety and efficacy.
Eight healthy male participants (body mass 79.9 ± 1.9 kg and body fat percentage 16.1 ± 3.8%) visited the laboratory (20 °C, 40% relative humidity) on four occasions. Following 30-min rest, physiological and perceptual measures were recorded. Participants were then fitted with the CAERvest® proof of concept (PoC) or prototype 1 (P1), 2 (P2) or 3 (P3) for 60 min. Temperature, cardiovascular and perceptual measures were recorded every 5 min. After cooling, the CAERvest® was removed and the torso checked for cold-related injuries.
Temperature measures significantly (p < 0.05) reduced pre to post in all trials. Larger reductions in core and skin temperatures were observed for PoC (-0.36 ± 0.18 and -1.55 ± 0.97 °C) and P3 (-0.36 ± 0.22 and -2.47 ± 0.82 °C), compared with P1 and P2. No signs of cold-related injury were observed at any stage.
This study demonstrates that the CAERvest® is an effective device for reducing body temperature in healthy normothermic individuals without presence of cold injury. Further research in healthy and clinical populations is warranted.
身体降温用于治疗中暑的高温个体，或使核心体温降至正常以下以实现神经保护。一种新型的、化学激活的无动力冷却装置CAERvest®，对其安全性和有效性进行了研究。
八名健康男性参与者（体重79.9±1.9千克，体脂率16.1±3.8%）分四次前往实验室（温度20°C，相对湿度40%）。休息30分钟后，记录生理和感知指标。然后让参与者佩戴CAERvest®概念验证（PoC）或原型1（P1）、2（P2）或3（P3），持续60分钟。每5分钟记录一次温度、心血管和感知指标。冷却结束后，取下CAERvest®，检查躯干是否有与寒冷相关的损伤。
在所有试验中，温度测量值从冷却前到冷却后均有显著降低（p<0.05）。与P1和P2相比，PoC（-0.36±0.18和-1.55±0.97°C）和P3（-0.36±0.22和-2.47±0.82°C）的核心温度和皮肤温度降低幅度更大。在任何阶段均未观察到与寒冷相关损伤的迹象。
本研究表明，CAERvest®是一种在健康体温正常个体中有效降低体温且不会造成寒冷损伤的装置。有必要在健康人群和临床人群中开展进一步研究。
