Jo In Young, Kim Shin-Wook, Son Seok Hyun
Department of Radiation Oncology, Samsung Medical Center, Seoul, Korea.
Department of Radiation Oncology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Oncotarget. 2017 Jan 10;8(2):3059-3063. doi: 10.18632/oncotarget.13830.
The purpose of this study was to evaluate the skin-sparing effects of 3-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) in patients with early left-sided breast cancer. Twenty left breast cancer patients treated with whole breast radiotherapy following breast-conserving surgery were enrolled in this study, and the 3D-CRT and IMRT plans were generated for each patient. To evaluate the dose delivered to the skin, 2 mm thickness skin (2-mm skin) and 3 mm thickness skin (3-mm skin) were contoured and a dosimetric comparison between the 2 plans was performed. The target volume coverage was better in IMRT than in 3D-CRT. The mean dose was 50.8 Gy for 3D-CRT and 51.1 Gy for IMRT. V40Gy was 99.4% for 3D-CRT and 99.9% for IMRT. In the case of skin, the mean dose was higher in 3D-CRT than in IMRT (mean dose of 2-mm skin: 32.8 Gy and 24.2 Gy; mean dose of 3-mm skin: 37.2 Gy and 27.8 Gy, for 3D-CRT and IMRT, respectively). These results indicated that the skin-sparing effect is more prominent in IMRT compared to 3D-CRT without compromising the target volume coverage.
本研究的目的是评估三维适形放疗（3D-CRT）和调强放疗（IMRT）对早期左侧乳腺癌患者的皮肤保护效果。本研究纳入了20例保乳手术后接受全乳放疗的左侧乳腺癌患者，并为每位患者制定了3D-CRT和IMRT计划。为了评估皮肤所接受的剂量，勾勒出2毫米厚皮肤（2-mm皮肤）和3毫米厚皮肤（3-mm皮肤）的轮廓，并对两种计划进行剂量学比较。IMRT的靶区覆盖优于3D-CRT。3D-CRT的平均剂量为50.8 Gy，IMRT为51.1 Gy。3D-CRT的V40Gy为99.4%，IMRT为99.9%。在皮肤方面，3D-CRT的平均剂量高于IMRT（3D-CRT和IMRT的2-mm皮肤平均剂量分别为32.8 Gy和24.2 Gy；3-mm皮肤平均剂量分别为37.2 Gy和27.8 Gy）。这些结果表明，与3D-CRT相比，IMRT在不影响靶区覆盖的情况下，皮肤保护效果更显著。
