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神经性疼痛专利的近期趋势。

Recent trends in neuropathic pain patents.

作者信息

Maia Rodolfo do Couto

机构信息

a Universidade Estácio de Sá - Petrópolis , Rio de Janeiro , Brazil.

出版信息

Expert Opin Ther Pat. 2017 May;27(5):539-546. doi: 10.1080/13543776.2017.1273349. Epub 2016 Dec 28.

Abstract

Neuropathic pain (NP) is one of the most important health problems faced nowadays. NP is a chronic disease that cannot be treated like other pain conditions because it is developed from a nerve injury that evolves into a permanent dysfunction of the central and/or peripheral nervous system. Therefore, it involves the participation of several systems and should be viewed as a multi-factorial disease that needs a whole new pharmacological strategy in order to achieve the desired pain relief. Areas covered: The Espacenet site was used as the main source in order to perform the patent research for NP treatment. This review covers the patents with relevant approaches for NP treatment from 2014 until today. Expert opinion: Our patent research has shown that there is not a consensus approach to treat NP in any of its forms. In our opinion, the approach regarding NP needs to be like cancer's approach. As there are different types of cancer and different ways to treat them, the same needs to be done for NP. Currently, there are several promising targets, which corroborates that this is a wide-open research area. For these reasons, neuropathic pain is a therapeutic field full of potential for innovation.

摘要

神经病理性疼痛(NP)是当今面临的最重要的健康问题之一。NP是一种慢性病,不能像其他疼痛病症那样进行治疗,因为它由神经损伤发展而来,进而演变成中枢和/或外周神经系统的永久性功能障碍。因此,它涉及多个系统的参与,应被视为一种多因素疾病,需要全新的药理学策略才能实现理想的疼痛缓解。涵盖领域:以欧洲专利局数据库网站作为主要来源,对NP治疗的专利进行检索。本综述涵盖了2014年至今采用相关方法治疗NP的专利。专家观点:我们的专利检索表明,对于任何形式的NP治疗,都不存在一种共识性的方法。在我们看来,NP的治疗方法需要像癌症的治疗方法一样。由于存在不同类型的癌症以及不同的治疗方法,NP也需要这样做。目前,有几个有前景的靶点,这证实了这是一个开放的研究领域。基于这些原因,神经病理性疼痛是一个充满创新潜力的治疗领域。

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