Highly selective A3 adenosine receptor agonists relieve chronic neuropathic pain.
作者信息
Salvemini Daniela, Jacobson Kenneth A
机构信息
a Department of Pharmacology and Physiology , Saint Louis University School of Medicine , St. Louis , MO , USA.
b Laboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases , National Institutes of Health , Bethesda , MD , USA.
出版信息
Expert Opin Ther Pat. 2017 Aug;27(8):967. doi: 10.1080/13543776.2017.1341018. Epub 2017 Jun 20.
Abstract
摘要
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本文引用的文献
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New perspectives for chronic pain treatment: a patent review (2010-2016).慢性疼痛治疗的新视角：一项专利综述（2010 - 2016年）
Expert Opin Ther Pat. 2017 Jul;27(7):787-796. doi: 10.1080/13543776.2017.1297425. Epub 2017 Mar 3.
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Recent trends in neuropathic pain patents.神经性疼痛专利的近期趋势。
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Role of A3 adenosine receptor in diabetic neuropathy.A3腺苷受体在糖尿病性神经病变中的作用
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Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.鉴定A3腺苷受体激动剂作为新型非麻醉性镇痛药。
Br J Pharmacol. 2016 Apr;173(8):1253-67. doi: 10.1111/bph.13446. Epub 2016 Mar 6.
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Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.刚性化A3腺苷受体激动剂：1-脱氮腺嘌呤修饰维持高体内疗效。
ACS Med Chem Lett. 2015 May 20;6(7):804-8. doi: 10.1021/acsmedchemlett.5b00150. eCollection 2015 Jul 9.
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Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.内源性腺苷A3受体激活可选择性减轻持续性疼痛状态。
Brain. 2015 Jan;138(Pt 1):28-35. doi: 10.1093/brain/awu330. Epub 2014 Nov 19.
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5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions.5'-氯-5'-脱氧-(±)-ENBA，一种强效且选择性的腺苷 A(1)受体激动剂，通过功能性神经胶质和小胶质细胞的改变缓解小鼠的神经性疼痛，而不影响运动或心血管功能。
Molecules. 2012 Nov 22;17(12):13712-26. doi: 10.3390/molecules171213712.
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The stimulation of A(3) adenosine receptors reduces bone-residing breast cancer in a rat preclinical model.A3 腺苷受体的刺激可减少大鼠临床前模型中的骨驻留乳腺癌。
Eur J Cancer. 2013 Jan;49(2):482-91. doi: 10.1016/j.ejca.2012.06.005. Epub 2012 Jul 5.
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Controlling murine and rat chronic pain through A3 adenosine receptor activation.通过激活 A3 腺苷受体来控制鼠类的慢性疼痛。
FASEB J. 2012 May;26(5):1855-65. doi: 10.1096/fj.11-201541. Epub 2012 Feb 17.
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A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.一种在大鼠中引发的周围性单神经病，可产生类似于人类所见的疼痛感觉障碍。
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