Kim Mi Kyoung, Park Hyung Seok, Kim Jee Ye, Kim Sanghwa, Nam Sanggeun, Park Seho, Kim Seung Il
Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
Department of Surgery, Yonsei University College of Medicine, Republic of Korea.
Am J Surg. 2017 Oct;214(4):726-732. doi: 10.1016/j.amjsurg.2016.10.019. Epub 2016 Nov 30.
The optimal number of sentinel lymph nodes (SLN) that need to be harvested to achieve favorable survival outcome during a SLN biopsy (SLNB) has not yet been established.
Six hundred and thirteen patients with clinically node-negative breast cancer who underwent SLNB were reviewed. Survival outcomes according to the number of total harvested lymph nodes (THLNs), defined as the sum of enumerated SLNs and non-SLNs were analyzed.
Patients with only 1 THLN showed lower recurrence-free survival (RFS) as compared to those with ≥2 THLNs (p = 0.049). In multivariate analysis, only 1 THLN was associated with poor RFS (HR = 2.711; p = 0.029).
Removing at least 2 lymph nodes during SLNB may be acceptable. Harvesting only 1 lymph node should be undertaken cautiously because of false negative results and increasing the subsequent recurrence rate.
前哨淋巴结活检（SLNB）过程中，为获得良好生存结果所需切除的前哨淋巴结（SLN）的最佳数量尚未确定。
回顾了613例接受SLNB的临床淋巴结阴性乳腺癌患者。分析了根据总切除淋巴结数（THLN）（定义为计数的SLN和非SLN之和）的生存结果。
与THLN≥2的患者相比，仅1个THLN的患者无复发生存率（RFS）较低（p = 0.049）。在多变量分析中，仅1个THLN与不良RFS相关（HR = 2.711；p = 0.029）。
SLNB期间切除至少2个淋巴结可能是可以接受的。由于假阴性结果和随后复发率增加，仅切除1个淋巴结应谨慎进行。
