Kvernby Sofia, Warntjes Marcel, Engvall Jan, Carlhäll Carl-Johan, Ebbers Tino
Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; SyntheticMR AB, Linköping, Sweden.
Magn Reson Imaging. 2017 May;38:13-20. doi: 10.1016/j.mri.2016.12.014. Epub 2016 Dec 18.
To investigate the in-vivo precision and clinical feasibility of 3D-QALAS - a novel method for simultaneous three-dimensional myocardial T1- and T2-mapping.
Ten healthy subjects and 23 patients with different cardiac pathologies underwent cardiovascular 3T MRI examinations including 3D-QALAS, MOLLI and T2-GraSE acquisitions. Precision was investigated in the healthy subjects between independent scans, between dependent scans and as standard deviation of consecutive scans. Clinical feasibility of 3D-QALAS was investigated for native and contrast enhanced myocardium in patients. Data were analyzed using mean value and 95% confidence interval, Pearson correlation, Paired t-tests, intraclass correlation and Bland-Altman analysis.
Average myocardial relaxation time values and SD from eight repeated acquisitions within the group of healthy subjects were 1178±18.5ms (1.6%) for T1 with 3D-QALAS, 52.7±1.2ms (2.3%) for T2 with 3D-QALAS, 1145±10.0ms (0.9%) for T1 with MOLLI and 49.2±0.8ms (1.6%) for T2 with GraSE. Myocardial T1 and T2 relaxation times obtained with 3D-QALAS correlated very well with reference methods; MOLLI for T1 (r=0.994) and T2-GraSE for T2 (r=0.818) in the 23 patients. Average native/post-contrast myocardial T1 values from the patients were 1166.2ms/411.8ms for 3D-QALAS and 1174.4ms/438.9ms for MOLLI. Average native myocardial T2 values from the patients were 53.2ms for 3D-QALAS and 54.4ms for T2-GraSE.
Repeated independent and dependent scans together with the intra-scan repeatability, demonstrated all a very good precision for the 3D-QALAS method in healthy volunteers. This study shows that 3D T1 and T2 mapping in the left ventricle is feasible in one breath hold for patients with different cardiac pathologies using 3D-QALAS.
研究3D-QALAS（一种同时进行三维心肌T1和T2映射的新方法）的体内精度和临床可行性。
10名健康受试者和23名患有不同心脏疾病的患者接受了心血管3T MRI检查，包括3D-QALAS、MOLLI和T2-GraSE采集。在健康受试者中，研究了独立扫描之间、相关扫描之间以及连续扫描的标准差的精度。在患者中，研究了3D-QALAS对天然心肌和对比增强心肌的临床可行性。使用平均值和95%置信区间、Pearson相关性、配对t检验、组内相关性和Bland-Altman分析对数据进行分析。
健康受试者组内八次重复采集的平均心肌弛豫时间值和标准差，3D-QALAS法T1为1178±18.5ms（1.6%），3D-QALAS法T2为52.7±1.2ms（2.3%），MOLLI法T1为1145±10.0ms（0.9%），GraSE法T2为49.2±0.8ms（1.6%）。3D-QALAS获得的心肌T1和T2弛豫时间与参考方法相关性很好；在23名患者中，T1与MOLLI相关（r=0.994），T2与T2-GraSE相关（r=0.818）。患者的平均天然/对比剂增强后心肌T1值，3D-QALAS法为1166.2ms/411.8ms，MOLLI法为1174.4ms/438.9ms。患者的平均天然心肌T2值，3D-QALAS法为53.2ms，T2-GraSE法为54.4ms。
重复的独立和相关扫描以及扫描内的可重复性，均表明3D-QALAS方法在健康志愿者中具有非常好的精度。本研究表明，使用3D-QALAS对患有不同心脏疾病的患者在一次屏气中进行左心室三维T1和T2映射是可行的。
