Department of Chemistry, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1021-1025. doi: 10.1002/anie.201610457. Epub 2016 Dec 21.
An efficient synthesis of biaryls through a gold-catalyzed oxidative cross-coupling of arenes with strong electron-deprived aryl boronates is presented herein. Regio- and chemocontrol are achieved by the selective activation of these coupling partners by gold at different oxidation states. Under reaction conditions devoid of basic additives or directing groups, the role of acetato ligand as an internal base has been revealed as a key parameter for expanding the reaction scope in these transformations.
本文报道了一种通过金催化的芳基硼酸酯与强缺电子芳基的氧化交叉偶联反应高效合成联芳烃的方法。通过金在不同氧化态下对这些偶联试剂的选择性活化，实现了区域和化学控制。在没有碱性添加剂或导向基团的反应条件下，醋酸根配体作为内部碱的作用被揭示为扩展这些转化中反应范围的关键参数。
