Mertens R Tyler, Greif Charles E, Coogle James T, Berger Gilles, Parkin Sean, Watson Mark D, Awuah Samuel G
Department of Chemistry, University of Kentucky, Lexington, KY 40506 USA.
Department of Medicinal Chemistry, Université libre de Bruxelles.
J Catal. 2022 Apr;408:109-114. doi: 10.1016/j.jcat.2022.02.019. Epub 2022 Feb 28.
The development of oxidant-free gold-catalyzed cross coupling reactions involving aryl halides have been hamstrung by the lack of gold catalysts capable of performing oxidative addition at Au(I) centers. Herein, we report the development of novel tricoordinate Au(I) catalysts supported by N,N-bidentate ligands and ligated by phosphine or arsine ligands for C-H functionalization without external oxidants to form biaryls with no homocoupling. The unsymmetrical character of the Au(I) catalyst is critical to facilitating this necessary orthogonal transformation. This study unveils yet another potential of Au(I) catalysis in biaryl synthesis.
涉及芳基卤化物的无氧化剂金催化交叉偶联反应的发展，因缺乏能够在金（I）中心进行氧化加成的金催化剂而受到阻碍。在此，我们报道了由N，N-双齿配体支撑并通过膦或胂配体配位的新型三配位金（I）催化剂的开发，用于在无外部氧化剂的情况下进行C-H官能化反应，以形成无自偶联的联芳基化合物。金（I）催化剂的不对称特性对于促进这种必要的正交转化至关重要。这项研究揭示了金（I）催化在联芳基合成中的另一种潜力。
