Zavareh Abbas Tavalaei, Jomhouri Rohollah, Bejestani Hadi Shahrad, Arshad Mahmoud, Daneshmand Mohammadali, Ziaei Hossein, Babadi Neda, Amiri Marzieh
Rom J Intern Med. 2016 Dec 1;54(4):217-221. doi: 10.1515/rjim-2016-0033.
Recent biochemical and physiological investigations have focused on the fundament of mood disorders in thyroid dysfunction. The present study aimed to address depressive disorder in a sample of Iranian hypothyroid women compared to euthyroid individuals.
Thirty consecutive hypothyroid female patients aged 25 to 40 years who referred to the Endocrinology and Metabolism Clinic at Rasoul-e-Akram Hospital in Tehran within a four-month period in 2015 were assessed. Thirty healthy euthyroid subjects matched for sex, age, and educational level were selected as the control. For assessment of depression status, Depression Anxiety Stress Scale-21 (DASS-21) was employed.
The study showed higher mean depression score in hypothyroid patients when compared to euthyroid ones (13.8 ± 9.5 versus 5.8 ± 5.2, p = 0.010). No significant association was revealed between mean depression score and patients' education level (p = 0.627), age (p = 0.967), occupation status (p = 0.211), and marital status (p = 0.556).
Hypothyroid women are predisposed to depressive symptoms independent of their baseline demographic and socioeconomic characteristics.
最近的生化和生理学研究聚焦于甲状腺功能障碍中情绪障碍的基础。本研究旨在比较伊朗甲状腺功能减退女性与甲状腺功能正常个体样本中的抑郁症情况。
对2015年在德黑兰拉苏勒 - 阿克拉姆医院内分泌与代谢门诊就诊的30例年龄在25至40岁之间的连续甲状腺功能减退女性患者进行评估。选择30名年龄、性别和教育水平相匹配的健康甲状腺功能正常受试者作为对照。采用抑郁焦虑压力量表21（DASS - 21）评估抑郁状态。
研究表明，甲状腺功能减退患者的平均抑郁评分高于甲状腺功能正常者（13.8±9.5对5.8±5.2，p = 0.010）。平均抑郁评分与患者的教育水平（p = 0.627）、年龄（p = 0.967）、职业状况（p = 0.211）和婚姻状况（p = 0.556）之间未发现显著关联。
甲状腺功能减退女性易患抑郁症状，且与她们的基线人口统计学和社会经济特征无关。
