Khazan M, Amouzegar A, Gharibzadeh S, Mehran L, Tohidi M, Azizi F
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Prevention of Metabolic disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Horm Metab Res. 2014 Dec;46(13):980-4. doi: 10.1055/s-0034-1389997. Epub 2014 Nov 4.
Hypothyroidism is a relatively common endocrine disorder usually accompanied with changes in serum lipid profiles. The purpose of this study was to assess the association between dyslipidemia and hypothyroidism in a population-based study. In this cross-sectional study, 2,315 dyslipidemic patients, aged 20-90 years (mean age: 38.1 ± 13.2 years), were selected from among 5,760 participants of Tehran Thyroid Study and divided into 3 groups, the subclinical hypothyroid, overt hypothyroid, and euthyroid subjects, based on national reference ranges. Serum lipid profiles, free thyroxine (FT4), thyroid stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb) were measured in all subjects. In subjects with dyslipidemia and nondyslipidemia, the prevalence of subclinical was 7% and 4.1%, respectively, and for clinical hypothyroidism 3% and 1.2%, respectively. In dyslipidemic subjects, the mean low density lipoprotein-cholesterol (LDL-C) levels differed significantly (p = 0.03) among the overt hypothyroid (144.3 ± 36.1), subclinical hypothyroid (129.3 ± 39.2), and euthyroid (132.7 ± 39.0) groups. In the overt hypothyroid group, mean total cholesterol level was higher than in the normal group, but not significant. There were no differences in median triglycerides (TG) and mean high density lipoprotein-cholesterol (HDL-C) levels among the 3 groups mentioned. After adjusting for age and sex, hypothyroidism was not related to elevated serum lipid profiles in patient with dyslipidemia. In conclusion, there is significant difference in the prevalence of subclinical and clinical hypothyroidism between nondyslipidemic and dyslipidemic subjects; after adjustment for age and sex the presence of dyslipidemia did not predict the presence of hypothyroidism.
甲状腺功能减退是一种相对常见的内分泌疾病，通常伴有血清脂质谱的变化。本研究的目的是在一项基于人群的研究中评估血脂异常与甲状腺功能减退之间的关联。在这项横断面研究中，从德黑兰甲状腺研究的5760名参与者中选取了2315名年龄在20 - 90岁（平均年龄：38.1±13.2岁）的血脂异常患者，并根据国家参考范围将其分为3组，即亚临床甲状腺功能减退组、显性甲状腺功能减退组和甲状腺功能正常组。对所有受试者测量血清脂质谱、游离甲状腺素（FT4）、促甲状腺激素（TSH）和甲状腺过氧化物酶抗体（TPOAb）。在血脂异常和非血脂异常的受试者中，亚临床甲状腺功能减退的患病率分别为7%和4.1%，临床甲状腺功能减退的患病率分别为3%和1.2%。在血脂异常的受试者中，显性甲状腺功能减退组（144.3±36.1）、亚临床甲状腺功能减退组（129.3±39.2）和甲状腺功能正常组（132.7±39.0）的平均低密度脂蛋白胆固醇（LDL - C）水平有显著差异（p = 0.03）。在显性甲状腺功能减退组中，平均总胆固醇水平高于正常组，但无统计学意义。上述3组之间的甘油三酯（TG）中位数和平均高密度脂蛋白胆固醇（HDL - C）水平无差异。在调整年龄和性别后，甲状腺功能减退与血脂异常患者血清脂质谱升高无关。总之，非血脂异常和血脂异常受试者中亚临床和临床甲状腺功能减退的患病率存在显著差异；在调整年龄和性别后，血脂异常的存在并不能预测甲状腺功能减退的存在。
