Peng Bo, Liu Chunrong, Li Zhen, Day Jacob J, Lu Yun, Lefer David J, Xian Ming
Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
Cardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
Bioorg Med Chem Lett. 2017 Feb 1;27(3):542-545. doi: 10.1016/j.bmcl.2016.12.023. Epub 2016 Dec 9.
Here we report the model studies of the reactions between NADH models (using HEH and BNAH) and sulfane sulfurs (using polysulfides). Such reactions could lead to the oxidation of NADH models and the production of hydrogen sulfide (HS). Kinetics of the reaction between BNAH and elemental sulfur S were determined in ethanol and the second-order rate constant was found to be 0.074Mmin (at 37°C) suggesting this is a slow process.
在此，我们报告了NADH模型（使用HEH和BNAH）与硫烷硫（使用多硫化物）之间反应的模型研究。此类反应可能导致NADH模型的氧化并产生硫化氢（HS）。在乙醇中测定了BNAH与元素硫S之间反应的动力学，发现二级速率常数为0.074M⁻¹min⁻¹（在37°C下），表明这是一个缓慢的过程。
