Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, University of Oregon , Eugene, Oregon 97403, United States.
Org Lett. 2017 May 5;19(9):2314-2317. doi: 10.1021/acs.orglett.7b00858. Epub 2017 Apr 25.
In an effort to expand the availability of simple polysulfides for HS donation, we report here the synthesis and HS release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release HS in a first-order dependence on reduced glutathione (GSH) and release more HS than the commonly used trisulfide DATS.
为了扩大简单多硫化物作为 HS 供体的可用性，我们在此报告了双（芳基）和双（烷基）四硫化物的合成和 HS 释放曲线。四硫化物供体以依赖于还原型谷胱甘肽 (GSH) 的一级反应释放 HS，并且比常用的三硫化物 DATS 释放更多的 HS。
