Wan Peixing, Su Wenru, Zhuo Yehong
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
J Med Genet. 2017 Jul;54(7):450-459. doi: 10.1136/jmedgenet-2016-104266. Epub 2016 Dec 21.
Long non-coding RNAs (lncRNAs) are remarkably powerful, flexible and pervasive cellular regulators. With the help of cheaper RNA-seq, high-throughput screening of lncRNAs has become widely applied and has identified large numbers of specific lncRNAs in various physiological or pathological processes. Vision is known to be a complex and vital perception that comprises 80% of the sensory information we receive. A consensus has been reached that normal visual maintenance and impairment are primarily driven by gene regulation. Recently, it has become understood that lncRNAs are key regulators in most biological processes, including cell proliferation, apoptosis, differentiation, immune responses, oxidative stress and inflammation. Our review is intended to provide insight towards a comprehensive view of the precise modulation of lncRNAs in visual maintenance and impairment. We also highlight the challenges and future directions in conducting lncRNA studies, particularly in patients whose lncRNAs may hold expanded promise for diagnostic, prognostic and therapeutic applications.
长链非编码RNA（lncRNAs）是非常强大、灵活且广泛存在的细胞调节因子。借助成本更低的RNA测序技术，lncRNAs的高通量筛选已得到广泛应用，并在各种生理或病理过程中鉴定出大量特异性lncRNAs。众所周知，视觉是一种复杂而重要的感知，我们所接收的感官信息中有80%来自视觉。人们已达成共识，正常视觉的维持和损害主要由基因调控驱动。最近，人们认识到lncRNAs是大多数生物过程中的关键调节因子，包括细胞增殖、凋亡、分化、免疫反应、氧化应激和炎症。我们的综述旨在深入全面地了解lncRNAs在视觉维持和损害中的精确调节作用。我们还强调了开展lncRNA研究面临的挑战和未来方向，特别是在lncRNAs在诊断、预后和治疗应用方面可能具有更大前景的患者中。
