Li Fang, Wen Xuyang, Zhang He, Fan Xianqun
Department of Ophthalmology, Ninth People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China.
Int J Mol Sci. 2016 Mar 31;17(4):478. doi: 10.3390/ijms17040478.
Recent advances have suggested that long noncoding RNAs (lncRNAs) are differentially expressed in ocular tissues and play a critical role in the pathogenesis of different types of eye diseases. Here, we summarize the functions and mechanisms of known aberrantly-expressed lncRNAs and present a brief overview of relevant reports about lncRNAs in such ocular diseases as glaucoma, proliferative vitreoretinopathy (PVR), diabeticretinopathy (DR), and ocular tumors. We intend to highlight comprehensive studies that provide detailed data about the mechanisms of lncRNAs, their applications as diagnostic or prognostic biomarkers, and their potential therapeutic targets. Although our understanding of lncRNAs is still in its infancy, these examples may provide helpful insights into the methods by which lncRNAs interfere with ocular diseases.
最近的研究进展表明，长链非编码RNA（lncRNAs）在眼部组织中存在差异表达，并在不同类型眼病的发病机制中发挥关键作用。在此，我们总结了已知异常表达的lncRNAs的功能和机制，并简要概述了关于lncRNAs在青光眼、增殖性玻璃体视网膜病变（PVR）、糖尿病视网膜病变（DR）和眼部肿瘤等眼部疾病中的相关报道。我们旨在重点介绍那些提供lncRNAs机制详细数据、其作为诊断或预后生物标志物的应用以及潜在治疗靶点的综合研究。尽管我们对lncRNAs的理解仍处于起步阶段，但这些实例可能为lncRNAs干扰眼部疾病的方式提供有益的见解。
