Gray Robert D M, Parker Kim H, Quail Michael A, Taylor Andrew M, Biglino Giovanni
CoMPLEX, University College London, London, United Kingdom.
Bioengineering Department, Imperial College London, London, United Kingdom.
MethodsX. 2016 Aug 25;3:508-512. doi: 10.1016/j.mex.2016.08.004. eCollection 2016.
The reservoir-wave hypothesis states that the blood pressure waveform can be usefully divided into a "reservoir pressure" related to the global compliance and resistance of the arterial system, and an "excess pressure" that depends on local conditions. The formulation of the reservoir-wave hypothesis applied to the area waveform is shown, and the analysis is applied to area and velocity data from high-resolution phase-contrast cardiovascular magnetic resonance (CMR) imaging. A validation study shows the success of the principle, with the method producing largely robust and physically reasonable parameters, and the linear relationship between flow and wave pressure seen in the traditional pressure formulation is retained. The method was successfully tested on a cohort of 20 subjects (age range: 20-74 years; 17 males). This paper: •Demonstrates the feasibility of deriving reservoir data non-invasively from CMR.•Includes a validation cohort (CMR data).•Suggests clinical applications of the method.
弹性腔波假说指出，血压波形可有效分为与动脉系统整体顺应性和阻力相关的“弹性腔压力”，以及取决于局部条件的“过剩压力”。展示了应用于面积波形的弹性腔波假说公式，并将该分析应用于来自高分辨率相位对比心血管磁共振（CMR）成像的面积和速度数据。一项验证研究表明该原理是成功的，该方法产生的参数在很大程度上是稳健且符合物理原理的，并且保留了传统压力公式中流量与波压力之间的线性关系。该方法在20名受试者（年龄范围：20 - 74岁；17名男性）的队列中成功进行了测试。本文：•证明了从CMR无创获取弹性腔数据的可行性。•包括一个验证队列（CMR数据）。•提出了该方法的临床应用。
