[Heparin prophylaxis of thrombohemorrhagic complications in surgical interventions in cancer patients].

Patients with uterine (394), ovarian (272) and breast cancer (122) were followed postoperatively using complex clinico-biomicroscopic method. Control (no heparin) group 1 included 100 patients and control group 2 (prophylactic mini-doses of heparin pre- and postoperatively)--142. Intra- and postoperative heparin was administered for prevention of thrombohemorrhagic syndrome (THS) in a study group of 152 patients. Such complications as phlebothrombosis and bronchopneumonia occurred in 19% (control group 1), and phlebothrombosis--in 11.2% (control group 2), vascular bleeding--in 2 cases. Bleeding from open vessel was observed in 1 case of radical mastectomy (study group) and microhematuria--in 8 cases of uterine extirpation with the appendages. The study revealed chronic THS-type coagulation disturbances in uterine, ovarian and breast cancer patients as well as high effectiveness of prevention of their progression by intra- and postoperative heparin administration.