Nadiradze I Sh
Vopr Onkol. 1989;35(8):974-9.
Patients with uterine (394), ovarian (272) and breast cancer (122) were followed postoperatively using complex clinico-biomicroscopic method. Control (no heparin) group 1 included 100 patients and control group 2 (prophylactic mini-doses of heparin pre- and postoperatively)--142. Intra- and postoperative heparin was administered for prevention of thrombohemorrhagic syndrome (THS) in a study group of 152 patients. Such complications as phlebothrombosis and bronchopneumonia occurred in 19% (control group 1), and phlebothrombosis--in 11.2% (control group 2), vascular bleeding--in 2 cases. Bleeding from open vessel was observed in 1 case of radical mastectomy (study group) and microhematuria--in 8 cases of uterine extirpation with the appendages. The study revealed chronic THS-type coagulation disturbances in uterine, ovarian and breast cancer patients as well as high effectiveness of prevention of their progression by intra- and postoperative heparin administration.
采用综合临床生物显微镜检查法对子宫癌患者（394例）、卵巢癌患者（272例）和乳腺癌患者（122例）进行术后随访。对照组1（未使用肝素）有100例患者，对照组2（术前和术后使用小剂量预防性肝素）有142例患者。在一个由152例患者组成的研究组中，术中及术后给予肝素以预防血栓出血综合征（THS）。静脉血栓形成和支气管肺炎等并发症在对照组1中发生率为19%，静脉血栓形成在对照组2中发生率为11.2%，有2例发生血管出血。在1例根治性乳房切除术（研究组）中观察到开放血管出血，在8例子宫及附件切除术中观察到微血尿。研究发现子宫癌、卵巢癌和乳腺癌患者存在慢性THS型凝血障碍，以及术中及术后给予肝素预防其进展的高效性。
