Hassan Iffat, Zeerak Sumaya, Kuchay Sanaullah, Bashir Safia, Bhat Yasmeen J, Mubashir Syed, Rasool Farhan, Sheikh Gousia, Sajad Peerzada
Department of Dermatology, Sexually Transmitted Diseases and Leprosy, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Department of Radiation Oncology, Government Medical College Srinagar, University of Kashmir, Srinagar, Jammu and Kashmir, India.
Indian J Dermatol Venereol Leprol. 2017 Mar-Apr;83(2):276. doi: 10.4103/0378-6323.196321.
A wide variety of systemic diseases and internal malignancies have cutaneous manifestations. In the context of internal malignancy, many cutaneous changes are highly specific to the underlying malignancy, while other changes are nonspecific. Some changes are also due to the modalities employed in the treatment of malignancies.
Two hundred and fifty patients who were diagnosed with internal malignancy and who were attending the department of radiation oncology, were evaluated at the Department of Dermatology, Sexually Transmitted Diseases and Leprosy of Government Medical College, Srinagar. The study was conducted over a period of 5 months. Relevant investigations, wherever needed, were carried out.
Among the 250 cases examined, nonspecific cutaneous changes were seen in 39 (15.6%) cases, whereas specific skin lesions in the form of cutaneous metastases were seen in two (0.8%) patients. Nail changes and hair changes were also seen in some patients.
As this was a cross-sectional study and most of the patients were lost to follow up, we could not assess the outcome of the dermatological changes seen in the affected patients.
Many dermatological changes are noticed early in the course of malignancy, reflecting a strong association of the cutaneous change with malignancy. Few manifestations occur late in the course of the disease, indicating dissemination or immunosuppression. Some changes reflect radiation-induced or chemotherapy-induced toxicity, indicating the need for treatment modifications.
多种全身性疾病和体内恶性肿瘤都有皮肤表现。在体内恶性肿瘤的情况下，许多皮肤变化对潜在的恶性肿瘤具有高度特异性，而其他变化则是非特异性的。一些变化也归因于恶性肿瘤治疗中所采用的方式。
对250例被诊断为体内恶性肿瘤且正在放射肿瘤学科室就诊的患者，在斯利那加政府医学院皮肤病、性传播疾病和麻风病科进行了评估。该研究持续了5个月。必要时进行了相关检查。
在检查的250例病例中，39例（15.6%）出现了非特异性皮肤变化，而2例（0.8%）患者出现了以皮肤转移形式的特异性皮肤病变。部分患者还出现了指甲变化和毛发变化。
由于这是一项横断面研究，且大多数患者失访，我们无法评估受影响患者中所见皮肤变化的结果。
在恶性肿瘤病程早期就可注意到许多皮肤变化，这反映出皮肤变化与恶性肿瘤之间存在密切关联。少数表现出现在疾病后期，表明发生了扩散或免疫抑制。一些变化反映了放疗或化疗引起的毒性，表明需要调整治疗方案。
