Ayyamperumal A, Tharini Gk, Ravindran Vidhya, Parveen B
Department of Dermatology, Madras Medical College, Government General Hospital, Chennai, India.
Indian J Dermatol. 2012 Jul;57(4):260-4. doi: 10.4103/0019-5154.97657.
Many malignancies affecting the internal organs display cutaneous manifestations which may be either specific (tumor metastases) or nonspecific lesions.
The study is aimed at determining the frequency and significance of cutaneous manifestations among patients with internal malignancy.
750 cases of proven internal malignancy, who attended a cancer chemotherapy center in South India, were studied. Specific infiltrates were confirmed by histopathology, fine needle aspiration cytology (FNAC) and marker studies.
Out of the 750 patients with internal malignancy, skin changes were seen in a total of 52 (6.93%) patients.
Cutaneous metastases (specific lesions) were seen in 20 patients (2.66%): contiguous in 6 (0.8%), and non-contiguous in 14 (1.86%). Nonspecific skin changes were seen in 32 patients (4.26%). None of our patients presented with more than one type of skin lesions. Herpes zoster was the most common nonspecific lesion noticed in our patients, followed by generalized pruritus, multiple eruptive seborrheic keratoses, bullous disorder, erythroderma, flushing, purpura, pyoderma gangrenosum, insect bite allergy and lichenoid dermatitis.
许多影响内脏器官的恶性肿瘤会出现皮肤表现，这些表现可能是特异性的（肿瘤转移）或非特异性病变。
本研究旨在确定内脏恶性肿瘤患者中皮肤表现的发生率及意义。
对750例确诊为内脏恶性肿瘤且在印度南部一家癌症化疗中心就诊的患者进行了研究。通过组织病理学、细针穿刺细胞学检查（FNAC）和标志物研究来确诊特异性浸润。
在750例内脏恶性肿瘤患者中，共有52例（6.93%）出现了皮肤改变。
20例（2.66%）出现皮肤转移（特异性病变）：6例（0.8%）为连续性转移，14例（1.86%）为非连续性转移。32例（4.26%）出现非特异性皮肤改变。我们的患者均未出现超过一种类型的皮肤病变。带状疱疹是我们患者中最常见的非特异性病变，其次是全身性瘙痒、多发性脂溢性角化病、大疱性疾病、红皮病、潮红、紫癜、坏疽性脓皮病、昆虫叮咬过敏和苔藓样皮炎。
