Poole S, Fenske N A
Division of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa 33612.
J Am Acad Dermatol. 1993 Jan;28(1):1-13. doi: 10.1016/0190-9622(93)70001-a.
Cutaneous findings often reflect the presence and course of an internal disease. Recognition of external clues is important to facilitate both early diagnosis and prompt treatment of the internal disorder. Early recognition is especially valuable in a patient with an internal malignant disease because intervention may significantly affect survival. In this two-part series, we review the spectrum of cutaneous markers of internal malignancy. Part I focuses on malignant involvement of the skin caused by either direct extension or metastases and the genodermatoses with malignant potential. Part II will be devoted to the paraneoplastic skin manifestations of internal malignancy as well as environmental carcinogens that produce cutaneous features. We also discuss some proposed but controversial associations between skin disease and internal malignancy.
皮肤表现常常反映出体内疾病的存在及其病程。识别外部线索对于促进内部疾病的早期诊断和及时治疗非常重要。早期识别对于患有体内恶性疾病的患者尤为重要，因为干预可能会显著影响生存率。在这个两部分的系列文章中，我们回顾了体内恶性肿瘤的皮肤标志物谱。第一部分重点关注由直接蔓延或转移引起的皮肤恶性受累以及具有恶性潜能的遗传性皮肤病。第二部分将致力于探讨体内恶性肿瘤的副肿瘤性皮肤表现以及产生皮肤特征的环境致癌物。我们还讨论了一些关于皮肤病与体内恶性肿瘤之间已提出但存在争议的关联。
