McDonald C P, Barbara J A, Contreras M, Brown S
North London Blood Transfusion Centre, Edgware, UK.
Vox Sang. 1989;57(1):55-8. doi: 10.1111/j.1423-0410.1989.tb04984.x.
Toxoplasma gondii has been reported to cause complications only in immunosuppressed patients receiving leucocyte transfusion, when severe acute toxoplasmosis has been reported with associated mortality. At the North London Blood Transfusion Centre (NLBTC) we have screened 392 plasmapheresis donors (using toxoreagent latex agglutination test manufactured by Eiken) to provide a panel of blood donors negative for antibody to toxoplasma for seronegative recipients. A toxoplasma-negative panel of donors would only be required for those rare instances when granulocyte concentrates are indicated for transfusion of seronegative recipients. The toxoreagent test classified the 392 blood donors as 36% positive, 23% weakly reactive and 41% negative; these negative sera were retested with toxoreagent and 17% of them reacted weakly but none were positive. The toxoreagent 'weakly-reactive' sera (all of which were Sabin-Feldman dye test negative) can probably best be accounted for by the exacting screening conditions under which we operated to ensure seronegativity in our special donor panel. 40% of the antibody-positive donors were female and 34% male. Seropositivity increased with age.
据报道，弓形虫仅在接受白细胞输血的免疫抑制患者中引发并发症，曾有严重急性弓形虫病伴相关死亡的报道。在北伦敦输血中心（NLBTC），我们对392名血浆置换供者进行了筛查（使用荣研公司生产的弓形虫试剂乳胶凝集试验），以提供一组针对弓形虫抗体呈阴性的献血者，供血清阴性受者使用。仅在极少数情况下，即当需要为血清阴性受者输注浓缩粒细胞时，才需要一组弓形虫阴性的供者。弓形虫试剂检测将392名献血者分类为36%呈阳性、23%弱阳性和41%阴性；对这些阴性血清用弓形虫试剂进行复测，其中17%呈弱阳性，但无一呈阳性。弓形虫试剂“弱阳性”血清（所有这些血清在Sabin-Feldman染料试验中均为阴性）很可能最好由我们为确保特殊供者组血清阴性而采用的严格筛查条件来解释。40%的抗体阳性供者为女性，34%为男性。血清阳性率随年龄增长而升高。
