Bellini C, Caulk A W, Li G, Tellides G, Humphrey J D
Department of Biomedical Engineering, Yale University, New Haven, CT 06520.
Department of Surgery, Yale School of Medicine, New Haven, CT 06520.
J Biomech Eng. 2017 Apr 1;139(4):0445011-6. doi: 10.1115/1.4035551.
The availability of diverse mouse models is revealing increasingly greater information on arterial mechanics, including homeostatic adaptations and pathologic maladaptations to genetic, pharmacological, and surgical manipulations. Fundamental to understanding such biomechanical changes, however, is reliable information on appropriate control vessels. In this paper, we contrast 15 different geometrical and mechanical metrics of biaxial wall mechanics for the ascending aorta across seven different types of possible control mice. We show that there is a comforting similarity across these multiple controls for most, though not all, metrics. In particular, three potential controls, namely, noninduced conditional mice, exhibit higher values of distensibility, an important clinical metric of structural stiffness, and two of these potential controls also have higher values of intrinsic circumferential material stiffness. There is motivation, therefore, to understand better the biomechanical changes that can arise with noninduced Cre-lox or similar approaches for generating mutations conditionally. In cases of germline mutations generated by breeding heterozygous +/- mice, however, the resulting homozygous +/+ mice tend to exhibit properties similar to traditional (C57BL/6) controls.
多种小鼠模型的出现揭示了越来越多关于动脉力学的信息，包括对基因、药理学和手术操作的稳态适应和病理适应不良。然而，理解此类生物力学变化的基础是有关合适对照血管的可靠信息。在本文中，我们对比了七种不同类型的可能对照小鼠升主动脉双轴壁力学的15种不同几何和力学指标。我们表明，对于大多数（尽管不是全部）指标，这些多种对照之间存在令人欣慰的相似性。特别是，三种潜在对照，即未诱导的条件性小鼠，表现出更高的扩张性值，这是结构刚度的一个重要临床指标，并且其中两种潜在对照还具有更高的固有周向材料刚度值。因此，有必要更好地理解通过未诱导的Cre-lox或类似方法产生条件性突变时可能出现的生物力学变化。然而，在通过繁殖杂合子+/-小鼠产生种系突变的情况下，所得的纯合子+/+小鼠往往表现出与传统（C57BL/6）对照相似的特性。
