Janssen Steffi M J, Abbink Jannie J, Lindeboom Robert, Vliet Vlieland Thea P M
Rijnlands Rehabilitation Center, Leiden, the Netherlands (Ms Janssen and Drs Abbink and Vliet Vlieland); University of Amsterdam, Amsterdam, the Netherlands (Dr Lindeboom); and Department of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Leiden, the Netherlands (Dr Vliet Vlieland).
J Cardiopulm Rehabil Prev. 2017 Jan;37(1):65-71. doi: 10.1097/HCR.0000000000000227.
Although rehabilitation after treatment for non-small cell lung cancer (NSCLC) was found to have a beneficial effect on exercise capacity in a number of studies, insight into its effect on quality of life (QoL) and fatigue is limited. The aim of this study was to examine the outcome of pulmonary rehabilitation (PR) regarding fatigue, QoL, and exercise capacity in adult patients curatively treated for NSCLC stages I to IIIa.
Study data were prospectively and routinely gathered in daily practice in patients taking part in an outpatient PR program after treatment for NSCLC stages I to IIIa. PR consisted of 12 weeks of supervised exercises 3 times a week, supplemented with scheduled visits with members of a multidisciplinary team. Data were gathered at initial assessment and discharge. Outcomes included fatigue (the Functional Assessment of Cancer Therapy-Fatigue and the fatigue domain of the Chronic Respiratory Disease Questionnaire); QoL (total CRQ score), Functional Assessment of Cancer Therapy-Lung, and the Short Form 36; and exercise capacity (cardiopulmonary exercise testing).
Fifty patients started the program out of the 70 patients referred to PR and 43 (86%) completed the program. Significant (P ≤ .01) and clinically relevant improvements were observed for all outcome measures.
Rehabilitation after treatment for NSCLC stages I to IIIa showed promising improvements regarding patient fatigue, QoL, and exercise capacity. PR should be considered for patients after treatment for NSCLC stages I to IIIa.
尽管多项研究发现非小细胞肺癌（NSCLC）治疗后的康复对运动能力有有益影响，但对其对生活质量（QoL）和疲劳影响的了解有限。本研究的目的是检查I至IIIa期NSCLC根治性治疗的成年患者在疲劳、生活质量和运动能力方面的肺康复（PR）结果。
前瞻性地并在日常实践中常规收集参与I至IIIa期NSCLC治疗后门诊PR项目患者的研究数据。PR包括每周3次、为期12周的监督锻炼，并辅以与多学科团队成员的定期会诊。在初始评估和出院时收集数据。结果包括疲劳（癌症治疗功能评估-疲劳量表和慢性呼吸系统疾病问卷中的疲劳领域）；生活质量（慢性呼吸系统疾病问卷总分）、癌症治疗功能评估-肺部量表和简明健康状况调查量表；以及运动能力（心肺运动测试）。
在转介至PR的70名患者中，50名开始了该项目，43名（86%）完成了该项目。所有结果指标均观察到显著（P≤0.01）且具有临床意义的改善。
I至IIIa期NSCLC治疗后的康复在患者疲劳、生活质量和运动能力方面显示出有希望的改善。I至IIIa期NSCLC治疗后的患者应考虑进行肺康复。
