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可切除肺癌患者康复期间健康相关生活质量的变化：一项可行性研究（PROLUCA）

Changes in Health-Related Quality of Life During Rehabilitation in Patients With Operable Lung Cancer: A Feasibility Study (PROLUCA).

作者信息

Sommer Maja S, Trier Karen, Vibe-Petersen Jette, Christensen Karl B, Missel Malene, Christensen Merete, Larsen Klaus R, Langer Seppo W, Hendriksen Carsten, Clementsen Paul F, Pedersen Jesper H, Langberg Henning

机构信息

1 Copenhagen Centre for Cancer and Health, Copenhagen, Denmark.

2 University of Copenhagen, Copenhagen, Denmark.

出版信息

Integr Cancer Ther. 2018 Jun;17(2):388-400. doi: 10.1177/1534735416668258. Epub 2016 Oct 3.

DOI:10.1177/1534735416668258
PMID:27698263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6041926/
Abstract

INTRODUCTION

Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life.

OBJECTIVES

The objective is to present health-related quality of life (HRQoL) changes over time before and 1 year after surgery in patients with NSCLC participating in a rehabilitation program.

METHODS

Forty patients with NSCLC in disease stage I to IIIa, referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, were included in the study. The rehabilitation program comprised supervised group exercise program, 2 hours weekly for 12 weeks, combined with individual counseling. The study endpoints were self-reported HRQoL (Functional Assessment of Cancer Therapy-Lung, European Organization for Research and Treatment in Cancer-Quality of Life Questionnaire-QLQ-C30, Short-Form-36) and self-reported distress, anxiety, depression, and social support (National Comprehensive Cancer Network Distress Thermometer, Hospital Anxiety and Depression Scale, Multidimensional Scale of Perceived Social Support), measured presurgery, postintervention, 6 months, and 1 year after surgery.

RESULTS

Forty patients were included, 73% of whom completed rehabilitation. Results on emotional well-being ( P < .0001), global quality of life ( P = .0032), and mental health component score ( P = .0004) showed an overall statistically significant improvement during the study.

CONCLUSION

This feasibility study demonstrated that global quality of life, mental health, and emotional well-being improved significantly during the study, from time of diagnosis until 1 year after resection, in patients with NSCLC participating in rehabilitation.

摘要

引言

非小细胞肺癌（NSCLC）患者进行手术切除可能会伴有显著的发病率、功能受限以及生活质量下降。

目的

旨在呈现参与康复计划的NSCLC患者术前及术后1年随时间变化的健康相关生活质量（HRQoL）。

方法

纳入了40例疾病分期为I至IIIa期、转诊至丹麦哥本哈根大学 Rigshospitalet 医院心胸外科进行手术切除的NSCLC患者。康复计划包括有监督的团体运动计划，每周2小时，共12周，同时结合个体咨询。研究终点为自我报告的HRQoL（癌症治疗功能评估-肺癌量表、欧洲癌症研究与治疗组织生活质量问卷-QLQ-C30、简短健康调查问卷-36）以及自我报告的痛苦、焦虑、抑郁和社会支持（美国国立综合癌症网络痛苦温度计、医院焦虑抑郁量表、多维感知社会支持量表），在术前、干预后、术后6个月及术后1年进行测量。

结果

纳入40例患者，其中73%完成了康复。情绪健康（P <.0001）、总体生活质量（P =.0032）和心理健康成分得分（P =.0004）的结果显示，在研究期间总体有统计学意义上的显著改善。

结论

这项可行性研究表明，参与康复的NSCLC患者从诊断时到切除术后1年，在研究期间总体生活质量、心理健康和情绪健康均有显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974a/6041926/787ab6286fe4/10.1177_1534735416668258-fig17.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/974a/6041926/787ab6286fe4/10.1177_1534735416668258-fig17.jpg

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