Koto Masashi, Hasegawa Azusa, Takagi Ryo, Ikawa Hiroaki, Naganawa Kensuke, Mizoe Jun-Etsu, Jingu Keiichi, Tsujii Hirohiko, Tsuji Hiroshi, Kamada Tadashi, Okamoto Yoshitaka
Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences, Chiba, Japan.
Nagoya Proton Therapy Center, Nagoya, Japan.
Head Neck. 2017 Apr;39(4):724-729. doi: 10.1002/hed.24671. Epub 2016 Dec 22.
The purpose of this study was to present our evaluation of the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for locally advanced parotid gland carcinomas.
Clinicopathological features and outcomes were evaluated in 46 patients receiving C-ion RT for parotid gland carcinomas.
Sixteen patients had adenoid cystic carcinoma; 8 had adenocarcinoma, 8 had mucoepidermoid carcinoma, and 14 had other carcinomas. T2, T3, T4a, and T4b diseases were diagnosed in 3, 18, 8, and 17 patients, respectively. C-ion RT was provided to 25 patients as the primary treatment, to 20 patients for local recurrences after surgery, and to 1 patient for residual tumor after surgery. During follow-up (median duration, 62 months), 5-year local control and overall survival (OS) rates were 74.5% and 70.1%, respectively. Of the 30 patients without facial nerve palsy before C-ion RT, 25 showed no radiation-induced facial nerve palsy.
C-ion RT is effective and has acceptable toxicity levels for locally advanced parotid gland carcinomas. © 2016 Wiley Periodicals, Inc. Head Neck 39: 724-729, 2017.
本研究的目的是展示我们对碳离子放疗（C离子放疗）治疗局部晚期腮腺癌的安全性和有效性的评估。
对46例接受C离子放疗治疗腮腺癌的患者的临床病理特征和治疗结果进行评估。
16例患者为腺样囊性癌；8例为腺癌，8例为黏液表皮样癌，14例为其他类型癌症。分别有3、18、8和17例患者被诊断为T2、T3、T4a和T4b期疾病。25例患者接受C离子放疗作为主要治疗，20例患者接受C离子放疗用于术后局部复发，1例患者接受C离子放疗用于术后残留肿瘤。在随访期间（中位持续时间为62个月），5年局部控制率和总生存率（OS）分别为74.5%和70.1%。在C离子放疗前无面神经麻痹的30例患者中，25例未出现放射性面神经麻痹。
C离子放疗对局部晚期腮腺癌有效且毒性水平可接受。©2016威利期刊公司。《头颈》39: 724 - 729, 2017。
