Otorhinolaryngology Unit, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, 09124 Cagliari, Italy.
Pathology Unit, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, 09124 Cagliari, Italy.
Curr Oncol. 2023 Feb 23;30(3):2702-2714. doi: 10.3390/curroncol30030204.
This study aims to analyse a single-centre cohort series of patients who underwent parotidectomy for primary malignant parotid tumours. A retrospective chart review of 64 consecutive patients treated from November 2010 to March 2022 was performed. Outcomes were analysed by Kaplan-Meier curves. Sixty-four patients with a primary parotid malignancy were included in the study, with one bilateral case in this cohort. Patients were classified as stage I-II in 39 cases and stage III-IV in 26 cases. The five-year overall survival (OS), disease-specific survival (DSS), local relapse-free survival (LRFS), and distant metastasis-free survival (DMFS) rates were 78.4%, 89%, 92.5%, and 87.1%, respectively. Univariate analysis showed that high-risk histology, stage IV disease, lymphovascular invasion, perineural invasion, node metastasis, skin involvement, facial nerve involvement, and positive or close margins were risk factors associated with poorer outcomes. At present, the best evidence suggests that radical surgery should be the standard approach, and adjuvant therapy, in terms of radiotherapy/chemoradiotherapy, is recommended in patients with risk factors.
本研究旨在分析一组因原发性腮腺恶性肿瘤而行腮腺切除术的单中心队列患者。对 2010 年 11 月至 2022 年 3 月期间治疗的 64 例连续患者进行了回顾性图表审查。通过 Kaplan-Meier 曲线分析了结果。本研究纳入了 64 例原发性腮腺恶性肿瘤患者，其中该队列中有 1 例双侧病例。39 例患者分期为 I-II 期，26 例患者分期为 III-IV 期。五年总生存率（OS）、疾病特异性生存率（DSS）、局部无复发生存率（LRFS）和远处无转移生存率（DMFS）分别为 78.4%、89%、92.5%和 87.1%。单因素分析显示，高危组织学、IV 期疾病、脉管侵犯、神经周围侵犯、淋巴结转移、皮肤受累、面神经受累以及阳性或切缘接近是与较差预后相关的危险因素。目前，最佳证据表明，根治性手术应作为标准治疗方法，对于有危险因素的患者，建议行放疗/放化疗辅助治疗。
