Termisoflavones A-C，来源于与白蚁共生的链霉菌 RB1 的异黄酮糖苷。

Termisoflavones A-C, Isoflavonoid Glycosides from Termite-Associated Streptomyces sp. RB1.

机构信息

School of Pharmacy, Sungkyunkwan University , Suwon 440-746, Republic of Korea.

Leibniz Institute for Natural Product Research and Infection Biology e.V., Hans-Knöll-Institute (HKI) , Beutenbergstrasse 11a, 07745 Jena, Germany.

出版信息

J Nat Prod. 2016 Dec 23;79(12):3072-3078. doi: 10.1021/acs.jnatprod.6b00738. Epub 2016 Dec 2.

DOI:10.1021/acs.jnatprod.6b00738

PMID:28006913

Abstract

Three new isoflavonoid glycosides, termisoflavones A-C (1-3), and eight isoflavonoids (4-11) were isolated from termite-associated Streptomyces sp. RB1 recovered from the cuticle of the South African termite, Macrotermes natalensis. The structures of new compounds were determined by spectroscopic methods including 1D and 2D NMR and HR-MS analysis, as well as comparison of their NMR data with those of related isoflavonoid glycoside derivatives. The absolute configurations of the sugar moieties were clarified by chemical reactions. None of the isolates (1-11) displayed antifungal or antimicrobial activities (MICs > 100 μg/mL), whereas compounds 6 and 11 ameliorated cisplatin-induced kidney cell damage to 80% of the control value at a cisplatin dose of 25 μM.

摘要

从南非白蚁 Macrotermes natalensis 的外骨骼中分离到的白蚁共生链霉菌 RB1 中分离得到三种新的异黄酮苷，即 termisoflavones A-C（1-3），以及八种异黄酮（4-11）。新化合物的结构通过光谱方法确定，包括 1D 和 2D NMR 和 HR-MS 分析，以及与相关异黄酮苷衍生物的 NMR 数据比较。糖部分的绝对构型通过化学反应阐明。分离物（1-11）均无抗真菌或抗菌活性（MIC > 100 μg/mL），而化合物 6 和 11 在顺铂剂量为 25 μM 时将顺铂诱导的肾细胞损伤改善至对照值的 80%。