Hess L, Votava M, Málek J, Kurzová A, Slíva J
Department of Laboratory of Experimental Anesthesiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Department of Pharmacology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
Physiol Res. 2016 Dec 21;65(Suppl 4):S473-S480. doi: 10.33549/physiolres.933513.
Oxytocin is a hormone therapeutically used mainly for its peripheral effects during pregnancy in the uterus and breasts. However, additional central effects, i.e. anxiolytic effect, decreased level of social stress and increased empathy have been also observed. Hence, the aim of our study was to evaluate if nasal oxytocin can be used as anxiolytic substance in rhesus monkeys (n=20) and rabbits (n=20). Simultaneously, mean arterial blood pressure, arterial oxygen saturation of hemoglobin and pulse rate were monitored in all the evaluated animals. While rabbits lost righting reflex, monkeys developed a dose-dependent loss of aggressiveness and/or anxiety as evaluated by behavioral methods (aggressive behavior was classified as non-sedated - sedated - strongly sedated).
催产素是一种激素，在治疗上主要利用其在孕期对子宫和乳房的外周作用。然而，也观察到了它的其他中枢效应，即抗焦虑效应、社会压力水平降低和同理心增强。因此，我们研究的目的是评估鼻内催产素是否可作为恒河猴（n = 20）和兔子（n = 20）的抗焦虑物质。同时，对所有评估动物监测平均动脉血压、血红蛋白的动脉血氧饱和度和脉搏率。当兔子失去翻正反射时，通过行为方法评估，猴子出现了剂量依赖性的攻击性丧失和/或焦虑减轻（攻击行为分为未镇静 - 镇静 - 深度镇静）。
