Fridman Gabrielle, Rizzuti Allison E, Liao Jewel, Rolain Mark, Deutsch James A, Kaufman Stephen C
From the Department of Ophthalmology (Fridman, Rizzuti, Liao, Deutsch, Kaufman), State University of New York, Downstate Medical Center, Brooklyn, New York, and the Department of Ophthalmology (Rolain), Beaumont Hospital, Royal Oak, Michigan, USA.
From the Department of Ophthalmology (Fridman, Rizzuti, Liao, Deutsch, Kaufman), State University of New York, Downstate Medical Center, Brooklyn, New York, and the Department of Ophthalmology (Rolain), Beaumont Hospital, Royal Oak, Michigan, USA.
J Cataract Refract Surg. 2016 Dec;42(12):1774-1778. doi: 10.1016/j.jcrs.2016.10.012.
To study the effect of trypan blue on lens capsule elasticity and ease of completing a continuous curvilinear capsulorhexis (CCC) in a sheep lens model and to subsequently observe the effects of trypan blue in the surgical setting of 3 pediatric patients.
State University of New York, Downstate Medical Center, Brooklyn, New York, USA.
Prospective case series.
Twenty-four lenses were excised from fresh sheep globes. Twelve lenses were immersed in trypan blue for 2.5 minutes, and 12 lenses were immersed in a balanced salt solution for 2.5 minutes. Ease of completion of CCC was graded, and intralenticular pressure was quantified. A pediatric cataract surgeon used trypan blue to stain the lens capsules of 3 children during cataract surgery. The surgeon noted the effects of trypan blue on capsule elasticity and on the ease of completion of the CCC.
Lenses immersed in trypan blue had a mean score of 2.58 in ease of completion of capsulorhexis compared with the control group (1.5) (P = .031). Capsulorhexis was successfully completed in 91.7% of trypan blue cases compared with 58.3% of controls. Immersion in trypan blue decreased the intralenticular pressure by a mean of 4.5 mm Hg (P = .025). Successful capsulorhexis was completed in the 3 pediatric cases.
Trypan blue improved the success rate of CCC completion in the sheep lens by decreasing lens capsule elasticity.
None of the authors has a financial or proprietary interest in any material or method mentioned.
在羊晶状体模型中研究台盼蓝对晶状体囊弹性及连续环形撕囊（CCC）操作难易程度的影响，并随后观察台盼蓝在3例儿科患者手术中的效果。
美国纽约布鲁克林纽约州立大学下州医学中心。
前瞻性病例系列。
从新鲜羊眼球中取出24个晶状体。12个晶状体浸入台盼蓝中2.5分钟，12个晶状体浸入平衡盐溶液中2.5分钟。对完成CCC的难易程度进行分级，并对晶状体内部压力进行量化。一名儿科白内障外科医生在白内障手术期间使用台盼蓝对3名儿童的晶状体囊进行染色。该外科医生记录了台盼蓝对囊弹性及完成CCC难易程度的影响。
与对照组（1.5）相比，浸入台盼蓝的晶状体在完成撕囊的难易程度上平均得分为2.58（P = 0.031）。台盼蓝组91.7%的病例成功完成了撕囊，而对照组为58.3%。浸入台盼蓝使晶状体内部压力平均降低了4.5 mmHg（P = 0.025）。3例儿科病例均成功完成了撕囊。
台盼蓝通过降低晶状体囊弹性提高了羊晶状体中CCC完成的成功率。
作者均未对文中提及的任何材料或方法拥有财务或专利权益。
