Annefeld M
Z Rheumatol. 1989 Jul-Aug;48(4):188-93.
Systemic corticosteroid treatment induces morphological and functional changes in the articular cartilage similar to those in human osteoarthritis. In animal experiments the dexamethasone-induced inhibition of chondrocyte metabolism can be reduced in a dose-related manner by concomitant treatment with glycosaminoglycan-peptide complexes (GP-C)***). The metabolic changes in cartilage tissues of the joint and Processus Xiphoideus measured quantitatively by 35S-sulphate incorporation are comparable. The results indicate that GP-C could also have a dose-related effect on human osteoarthritic cartilage.
全身用皮质类固醇治疗可引起关节软骨形态和功能的改变，类似于人类骨关节炎中的变化。在动物实验中，通过同时使用糖胺聚糖 - 肽复合物（GP - C）***），地塞米松诱导的软骨细胞代谢抑制可呈剂量相关方式降低。通过35S - 硫酸盐掺入定量测量的关节软骨组织和剑突的代谢变化具有可比性。结果表明，GP - C对人类骨关节炎软骨也可能有剂量相关的作用。
