Moskowitz R W, Reese J H, Young R G, Fein-Krantz D, Malemud C J, Caplan A I
Department of Medicine, Case Western Reserve University, Cleveland, OH.
J Rheumatol. 1991 Feb;18(2):205-9.
The effects of Rumalon, a glycosaminoglycan peptide complex (GP-C), were evaluated in a partial meniscectomy model of osteoarthritis (OA). When rabbits were treated with Rumalon, 0.25 ml/kg 3 times/week for 12 weeks after partial meniscectomy, the proportion of animals that developed cartilage ulceration was lower than that in untreated meniscectomized rabbits (p less than 0.05). At 6 weeks sacrifice, the same dose of Rumalon was associated with a trend toward reduction in the number of animals with ulcerations. Rumalon administered at a dose of 0.5 ml/kg for 12 weeks reduced the number of animals with ulcers, although not at the p less than 0.05 level of significance. Semiquantitative histologic evaluations revealed no differences between control and treatment groups either in the thickness of articular cartilage, density of cells present, safranin-O stain or ratio of DNA/protein. Increased proteoglycan synthesis characteristic of OA was modulated toward normal in association with Rumalon therapy. Diminished OA changes in response to Rumalon are consistent with an ameliorative response to this agent in the partial meniscectomy model in the rabbit.
在骨关节炎（OA）的部分半月板切除术模型中评估了葡糖胺聚糖肽复合物（GP-C）鲁马隆的效果。在部分半月板切除术后，当用鲁马隆以0.25 ml/kg的剂量每周3次处理兔子，持续12周时，出现软骨溃疡的动物比例低于未处理的半月板切除兔子（p<0.05）。在处死6周时，相同剂量的鲁马隆与溃疡动物数量减少的趋势相关。以0.5 ml/kg的剂量给予鲁马隆12周可减少溃疡动物的数量，尽管未达到p<0.05的显著水平。半定量组织学评估显示，对照组和治疗组在关节软骨厚度、存在的细胞密度、番红O染色或DNA/蛋白质比例方面均无差异。与鲁马隆治疗相关，OA特有的蛋白聚糖合成增加被调节至正常水平。在兔子的部分半月板切除术模型中，对鲁马隆反应的OA变化减弱与对该药物的改善反应一致。
