脂肪组织：寄生虫的安全避风港？
Adipose Tissue: A Safe Haven for Parasites?
机构信息
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8549, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Trends Parasitol. 2017 Apr;33(4):276-284. doi: 10.1016/j.pt.2016.11.008. Epub 2016 Dec 19.
Abstract
Adipose tissue (AT) is no longer regarded as an inert lipid storage, but as an important central regulator in energy homeostasis and immunity. Three parasite species are uniquely associated with AT during part of their life cycle: Trypanosoma cruzi, the causative agent of Chagas disease; Trypanosoma brucei, the causative agent of African sleeping sickness; and Plasmodium spp., the causative agents of malaria. In AT, T. cruzi resides inside adipocytes, T. brucei is found in the interstitial spaces between adipocytes, while Plasmodium spp. infect red blood cells, which may adhere to the blood vessels supplying AT. Here, we discuss how each parasite species adapts to this tissue environment and what the implications are for pathogenesis, clinical manifestations, and therapy.
摘要
脂肪组织（AT）不再被视为惰性脂质储存库，而是作为能量平衡和免疫的重要中枢调节剂。有三种寄生虫物种在其生命周期的一部分中与 AT 独特相关：克氏锥虫，恰加斯病的病原体；布氏锥虫，非洲昏睡病的病原体；以及疟原虫，疟疾的病原体。在 AT 中，克氏锥虫存在于脂肪细胞内，布氏锥虫存在于脂肪细胞之间的间隙中，而疟原虫感染红细胞，这些红细胞可能附着在供应 AT 的血管上。在这里，我们讨论了每种寄生虫物种如何适应这种组织环境，以及这对发病机制、临床表现和治疗有何影响。
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