Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, Washington 98109, USA.
Nat Cell Biol. 2016 Dec 23;19(1):12-14. doi: 10.1038/ncb3458.
Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.
有丝分裂过程中染色体分离错误导致的染色质微核化可能会通过染色体重排导致大量的染色体重排。然而，基于微核的染色体重排的分子细节仍不清楚。现在，一种专门诱导 Y 染色体分离错误的精巧系统为这一过程提供了新的认识，包括非同源末端连接的作用。
