黄芩素的抗癌特性：综述
Anticancer properties of baicalein: a review.
作者信息
Gao Ying, Snyder Shane A, Smith Jaclyn N, Chen Yi Charlie
机构信息
College of Science, Technology & Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA; Department of Tea Science, Zhejiang University, Hangzhou 310058, China.
College of Science, Technology & Mathematics, Alderson Broaddus University, Philippi, WV 26416, USA.
出版信息
Med Chem Res. 2016 Aug;25(8):1515-1523. doi: 10.1007/s00044-016-1607-x. Epub 2016 Jun 29.
Abstract
The constituents of many traditional Chinese herbal remedies are currently at the forefront of modern cancer research. Baicalein, a bioactive flavone widely used in nutraceuticals and pharmaceuticals, has shown great potential in the treatment and prevention of cancer without causing severe side effects. Baicalein induces cancer cell apoptosis and cause cell cycle arrest. It shows inhibitory effects on angiogenesis, metastasis and inflammation, all of which are necessary for the promotion and progression of cancer. This review presents an overview of the anti-cancer effects and mechanisms of baicalein. In addition, the bioavailability of baicalein and approaches to improve it are summarized. Treatments of baicalein in combination with other anti-cancer agents are also mentioned.
摘要
许多传统中草药的成分目前处于现代癌症研究的前沿。黄芩素是一种广泛用于营养保健品和药品的生物活性黄酮，在癌症治疗和预防方面显示出巨大潜力，且不会引起严重副作用。黄芩素诱导癌细胞凋亡并导致细胞周期停滞。它对血管生成、转移和炎症具有抑制作用，而这些都是癌症发生和发展所必需的。本文综述了黄芩素的抗癌作用及其机制。此外，还总结了黄芩素的生物利用度及其改善方法。文中也提到了黄芩素与其他抗癌药物联合使用的治疗方法。
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