College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, China.
Arch Pharm Res. 2024 Sep;47(8-9):677-695. doi: 10.1007/s12272-024-01512-2. Epub 2024 Sep 22.
The main active constituents of plants of the Paeonia genus are known to have antitumor activity. Hundreds of compounds with a wide range of pharmacological activities, including monoterpene glycosides, flavonoids, tannins, stilbenes, triterpenoids, steroids, and phenolic compounds have been isolated. Among them, monoterpenes and their glycosides, flavonoids, phenolic acids, and other constituents have been shown to have good therapeutic effects on various cancers, with the main mechanisms including the induction of apoptosis; the inhibition of tumor cell proliferation, migration, and invasion; and the modulation of immunity. In this study, many citations related to the traditional uses, phytochemical constituents, antitumor effects, and clinical applications of the Paeonia genus were retrieved from popular and widely used databases such as Web of Science, Science Direct, Google Scholar, and PubMed using different search strings. A systematic review of the antitumor constituents of the Paeonia genus and their therapeutic effects on various cancers was conducted and the mechanisms of action and pathways of these phytochemicals were summarised to provide a further basis for antitumor research.
植物牡丹属的主要活性成分已被证实具有抗肿瘤活性。已经分离出数百种具有广泛药理活性的化合物，包括单萜糖苷、类黄酮、单宁、芪类、三萜类、甾体和酚类化合物。其中，单萜及其糖苷、类黄酮、酚酸等成分对多种癌症具有良好的治疗效果，主要机制包括诱导细胞凋亡、抑制肿瘤细胞增殖、迁移和侵袭以及调节免疫。在这项研究中，使用不同的搜索字符串，从 Web of Science、Science Direct、Google Scholar 和 PubMed 等流行且广泛使用的数据库中检索到与牡丹属植物的传统用途、植物化学成分、抗肿瘤作用以及临床应用相关的大量引文。对牡丹属植物的抗肿瘤成分及其对各种癌症的治疗作用进行了系统评价，并总结了这些植物化学物质的作用机制和途径，为抗肿瘤研究提供了进一步的基础。
