Hegde Madhu, P R Archana, Mumbrekar Kamalesh Dattaram
Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Heliyon. 2024 Nov 28;10(23):e40809. doi: 10.1016/j.heliyon.2024.e40809. eCollection 2024 Dec 15.
Despite years of development in cancer therapy, achieving successful cancer treatment remains a major research topic. Primary means of cancer treatment include chemotherapy, radiotherapy, and surgery. However, these modalities are associated with limitations and adverse effects on normal tissues. Therefore, there is a search for novel therapeutic approaches that will increase the efficacy of the available treatment while minimizing side effects. Naturally occurring bioactive chemicals such as flavonoids have long been used in traditional medicine to treat various illnesses. Baicalein, an active ingredient in Georgi, is utilised in traditional medicine to treat conditions such as hypertension, cardiovascular disease, inflammation, and infections. This review focuses on summarizing the data available on cancer prevention and treatment usage of baicalein. Baicalein is thought to prevent cancer progression by inducing apoptosis, autophagy, and genome instability, and its ability to promote chemo-potentiation, anti-metastatic effects, and regulate specific signalling molecules and transcription factors. Baicalein can be a promising option for cancer treatment, either alone or in combination with established anticancer drugs.
尽管癌症治疗已经发展了多年，但实现成功的癌症治疗仍然是一个主要的研究课题。癌症治疗的主要手段包括化疗、放疗和手术。然而，这些治疗方式存在局限性，并会对正常组织产生不良影响。因此，人们正在寻找新的治疗方法，以提高现有治疗的疗效，同时将副作用降至最低。天然存在的生物活性化学物质，如黄酮类化合物，长期以来一直被用于传统医学中治疗各种疾病。黄芩苷是黄芩中的一种活性成分，在传统医学中用于治疗高血压、心血管疾病、炎症和感染等病症。这篇综述着重总结了有关黄芩苷在癌症预防和治疗方面的现有数据。黄芩苷被认为可通过诱导细胞凋亡、自噬和基因组不稳定来预防癌症进展，以及其促进化疗增敏、抗转移作用和调节特定信号分子及转录因子的能力。黄芩苷无论是单独使用还是与已有的抗癌药物联合使用，都可能成为癌症治疗的一个有前景的选择。
