Sharma Pooja, Pal Deeksha, Gill Anita Rani, Gupta Mahiti, Goyal Soniya, Bansal Poonam, Sharma Ujjawal, Mathkor Darin Mansor, Haque Shafiul, Kaur Damandeep, SinghTuli Hardeep
Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to Be University), Mullana, India.
Department of Biotechnology, Guru Jambheshwar University of Science and Technology, Hisar, India.
Med Oncol. 2024 Dec 24;42(1):35. doi: 10.1007/s12032-024-02587-z.
Gastrointestinal cancer is a malignant condition of the gastrointestinal tract (GI) which affect multi-organs of digestive system, such as esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum, and anus. Gastrointestinal cancer is a 5th most common malignant cancer and 4th major cause in cancer-related mortality rate. Various significant facilities are available that have reduced the radio-resistance, chemo-resistance, and their adverse side effects. However, there are serious side effects associated with chemical and radiations during the process. Baicalein is a natural flavonoid extracted from dried roots of Scutellaria baicalensis, showing anti-cancerous property. It is also participating in inhibiting metastasis, accelerating apoptosis and elevating autophagy through inhibition of inflammation and cell proliferation. In this review, we have focused on Chemistry and pharmacokinetics of Baicalein for drug designing and clinical applications majorly in gastrointestinal cancer. Moreover, various types of cancer related to gastrointestinal, role of nanotechnology, and its synergism for reducing cancer are also discussed. Thus, the review would be beneficial to explore the role of baicalein against gastrointestinal cancer treatment.
胃肠道癌是一种发生于胃肠道（GI）的恶性疾病，可影响消化系统的多个器官，如食管、胃、胆道系统、胰腺、小肠、大肠、直肠和肛门。胃肠道癌是第五大常见恶性肿瘤，也是癌症相关死亡率的第四大主要原因。现在有各种先进的设备，降低了放射抗性、化学抗性及其副作用。然而，在此过程中，化学治疗和放射治疗仍存在严重的副作用。黄芩素是一种从黄芩干燥根中提取的天然黄酮类化合物，具有抗癌特性。它还通过抑制炎症和细胞增殖参与抑制转移、加速细胞凋亡和增强自噬。在这篇综述中，我们主要关注黄芩素的化学性质和药代动力学，以便将其用于药物设计和主要针对胃肠道癌的临床应用。此外，还讨论了各种胃肠道相关癌症类型、纳米技术的作用及其在抗癌方面的协同作用。因此，本综述将有助于探索黄芩素在胃肠道癌治疗中的作用。
