Li A, Robiou-du-Pont S, Anand S S, Morrison K M, McDonald S D, Atkinson S A, Teo K K, Meyre D
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Pediatr Obes. 2018 Mar;13(3):133-140. doi: 10.1111/ijpo.12205. Epub 2016 Dec 23.
The genetic influence on child obesity has not been fully elucidated.
This study investigated the parental and child contributions of 83 adult body mass index (BMI)-associated single-nucleotide polymorphisms (SNPs) to obesity-related traits in children from birth to 5 years old.
A total of 1402 individuals were genotyped for 83 SNPs. An unweighted genetic risk score (GRS) was generated by the sum of BMI-increasing alleles. Repeated weight and length/height were measured at birth, 1, 2, 3 and 5 years of age, and age-specific and sex-specific weight and BMI Z-scores were computed.
The GRS was significantly associated with birthweight Z-score (P = 0.03). It was also associated with weight/BMI Z-score gain between birth and 5 years old (P = 0.02 and 6.77 × 10 , respectively). In longitudinal analyses, the GRS was associated with weight and BMI Z-score from birth to 5 years (P = 5.91 × 10 and 5.08 × 10 , respectively). The maternal effects of rs3736485 in DMXL2 on weight and BMI variation from birth to 5 years were significantly greater compared with the paternal effects by Z test (P = 1.53 × 10 and 3.75 × 10 , respectively).
SNPs contributing to adult BMI exert their effect at birth and in early childhood. Parent-of-origin effects may occur in a limited subset of obesity predisposing SNPs.
遗传因素对儿童肥胖的影响尚未完全阐明。
本研究调查了83个与成人身体质量指数（BMI）相关的单核苷酸多态性（SNP）在父母及子女方面对0至5岁儿童肥胖相关性状的影响。
对1402名个体进行了83个SNP的基因分型。通过增加BMI的等位基因总和生成未加权遗传风险评分（GRS）。在出生时、1岁、2岁、3岁和5岁时测量体重和身长/身高，并计算特定年龄和性别的体重及BMI Z评分。
GRS与出生体重Z评分显著相关（P = 0.03）。它还与出生至5岁期间的体重/BMI Z评分增加相关（分别为P = 0.02和6.77×10）。在纵向分析中，GRS与出生至5岁的体重和BMI Z评分相关（分别为P = 5.91×10和5.08×10）。通过Z检验，与父亲的影响相比，DMXL2基因中rs3736485对出生至5岁体重和BMI变化的母亲影响显著更大（分别为P = 1.53×10和3.75×10）。
影响成人BMI的SNP在出生时和幼儿期发挥作用。肥胖易感SNP的亲本效应可能发生在有限的子集中。
