Mei Hong, Guo Siyu, Lu Hongyan, Pan Yunhong, Mei Wenhua, Zhang Bin, Zhang Jianduan
Department of Maternal and Child Health Care, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
BMJ Open. 2018 Jun 19;8(6):e018755. doi: 10.1136/bmjopen-2017-018755.
To understand whether parents' weight status before conception predicts body mass index (BMI) of their offspring in early life and the differences between the mother-child and father-child associations.
A birth cohort study.
Conducted at the Community Health Service Centre in Shenyang, Wuhan and Guangzhou.
A total of 2220 live birth newborns were recruited randomly after consent of their parents, and 1178 were followed up until 2 years old.
Parental demographics, maternal characteristics during pregnancy, children's anthropometric data and feeding patterns at 1 month old were collected. BMI was calculated and BMI Z-scores (BMI_Z) were generated by referring to WHO growth standard. Parental weight status was categorised into underweight, normal weight, and overweight and obese according to the Working Group of Obesity in China. General linear models and generalised linear models were used to assess the associations between parents and offspring.
The primary outcomes were descriptive data on child's sex-specific anthropometric variables. The secondary outcomes were BMI_Z and weight status of children at each time point.
No gender difference was observed in BMI_Z or overweight or obesity rates from birth to 24 months old, although boys were significantly heavier and had a greater length/height than girls (P<0.05). The overweight and obesity rates of children peaked at 12 months old. Maternal BMI/weight status had a significant but small effect on BMI_Z at birth, but not on the paternal side. The impact of parental BMI on child's BMI_Z after birth was similar at each follow-up. Offspring with underweight mothers tend to have reduced BMI_Z after birth while overweight/obese fathers had children with a greater BMI_Z.
Maternal weight status had small effect on both fetal and child growth after birth. Significant but mild paternal influence was only detected after birth.
了解孕前父母的体重状况是否能预测其后代早期的体重指数（BMI），以及母子和父子关联之间的差异。
一项出生队列研究。
在沈阳、武汉和广州的社区卫生服务中心进行。
在获得父母同意后，随机招募了2220名活产新生儿，其中1178名随访至2岁。
收集父母的人口统计学数据、孕期母亲的特征、儿童的人体测量数据以及1个月大时的喂养模式。计算BMI，并参照世界卫生组织生长标准生成BMI Z评分（BMI_Z）。根据中国肥胖问题工作组的标准，将父母的体重状况分为体重过轻、正常体重、超重和肥胖。使用一般线性模型和广义线性模型来评估父母与后代之间的关联。
主要观察指标是儿童性别特异性人体测量变量的描述性数据。次要观察指标是各时间点儿童的BMI_Z和体重状况。
从出生到24个月，BMI_Z或超重/肥胖率未观察到性别差异，尽管男孩比女孩明显更重，身长/身高更高（P<0.05）。儿童超重和肥胖率在12个月时达到峰值。母亲的BMI/体重状况对出生时的BMI_Z有显著但较小的影响，但父亲方面则没有。在每次随访中，父母BMI对儿童出生后BMI_Z的影响相似。母亲体重过轻的后代出生后BMI_Z往往降低，而父亲超重/肥胖的儿童BMI_Z更高。
母亲体重状况对胎儿和出生后儿童生长的影响较小。仅在出生后检测到显著但轻微的父亲影响。
