de Prost Y, Bodemer C, Teillac D
Unité de Dermatologie, Hôpital Necker Enfants Malades, Paris, France.
Acta Derm Venereol Suppl (Stockh). 1989;144:136-8. doi: 10.2340/00015555144136138.
The efficacy of local applications of 10% cyclosporin gel was studied in a randomised double-blind placebo-controlled trial in atopic dermatitis. Twenty atopic patients, presenting with stable symmetrical lesions, participated in the study. They applied cyclosporin gel to one side and placebo gel to the other side twice a day. The lesions were assessed on day 0 and day 14 according to lesional criteria scored from 0 to 3. The mean score for each criterion on day 14 was significantly lower on the sides treated with cyclosporin than on the sides treated with placebo. The total mean score on day 14 was 6.1 +/- 3.9 on the sides treated with CSA and 9.6 +/- 3.9 for placebo (p less than 0.005). These findings suggest the efficacy of local CSA applications on lesions of atopic dermatitis.
在一项针对特应性皮炎的随机双盲安慰剂对照试验中，研究了局部应用10%环孢素凝胶的疗效。20名患有稳定对称性皮损的特应性患者参与了该研究。他们每天两次在一侧涂抹环孢素凝胶，在另一侧涂抹安慰剂凝胶。在第0天和第14天根据从0到3评分的皮损标准对皮损进行评估。在第14天，环孢素治疗侧每个标准的平均评分显著低于安慰剂治疗侧。第14天，环孢素治疗侧的总平均评分为6.1±3.9，安慰剂治疗侧为9.6±3.9（p<0.005）。这些发现表明局部应用环孢素对特应性皮炎皮损有效。
