ARC Centre of Excellence for Engineered Quantum Systems, School of Physics, University of Sydney , Sydney, New South Wales 2006, Australia.
J Am Chem Soc. 2017 Jan 11;139(1):193-199. doi: 10.1021/jacs.6b09293. Epub 2016 Dec 23.
The widespread use of nanodiamond as a biomedical platform for drug-delivery, imaging, and subcellular tracking applications stems from its nontoxicity and unique quantum mechanical properties. Here, we extend this functionality to the domain of magnetic resonance, by demonstrating that the intrinsic electron spins on the nanodiamond surface can be used to hyperpolarize adsorbed liquid compounds at low fields and room temperature. By combining relaxation measurements with hyperpolarization, spins on the surface of the nanodiamond can be distinguished from those in the bulk liquid. These results are likely of use in signaling the controlled release of pharmaceutical payloads.
纳米金刚石作为药物输送、成像和亚细胞追踪应用的生物医学平台得到了广泛应用，这源于其无毒和独特的量子力学性质。在这里，我们通过证明纳米金刚石表面上的固有电子自旋可用于在低场和室温下使吸附的液体化合物超极化，将这种功能扩展到磁共振领域。通过将弛豫测量与极化相结合，可以区分纳米金刚石表面上的自旋和体相液体中的自旋。这些结果可能有助于信号控制药物有效成分的释放。
