Babizhayev M A
Moscow Helmholtz Research Insitute of Eye Diseases, USSR.
Acta Ophthalmol (Copenh). 1989 Aug;67(4):371-7. doi: 10.1111/j.1755-3768.1989.tb01617.x.
UV-spectrophotometry and fluorescent analysis were used to study lipid extracts from lenses, aqueous humour and blocks containing trabecular and Schlemms canal tissues, obtained from 49 eyes of patients with primary open-angle glaucoma (POAG). Accumulation of the primary, secondary, and end products of lipid peroxidation (LPO) (diene and triene conjugates, Schiff's bases) was noted in the studied extracts. Significant differences in the levels of all the mentioned LPO products in comparison with the control were observed. The data may be considered as an evidence of LPO participation in destruction of the trabecule and Schlemm's canal in POAG.
采用紫外分光光度法和荧光分析法，对从49例原发性开角型青光眼（POAG）患者的眼睛获取的晶状体、房水以及含有小梁和施莱姆管组织的组织块中的脂质提取物进行了研究。在所研究的提取物中，发现脂质过氧化（LPO）的初级、次级和终产物（二烯和三烯共轭物、席夫碱）有所积累。与对照组相比，所有上述LPO产物的水平均存在显著差异。这些数据可被视为LPO参与POAG中小梁和施莱姆管破坏的证据。
