Lacombe Jerome, Zenhausern Frederic
Center for Applied NanoBioscience and Medicine, University of Arizona, 145 S. 79th Street, Chandler, AZ 85226, USA.
Center for Applied NanoBioscience and Medicine, University of Arizona, 145 S. 79th Street, Chandler, AZ 85226, USA; Translational Genomics Research Institute, 445 N. Fifth Street, Phoenix, AZ 85004, USA; Department of Basic Medical Sciences, College of Medicine Phoenix, 425 N. 5th Street, Phoenix, AZ 85004, USA.
Crit Rev Oncol Hematol. 2017 Jan;109:69-78. doi: 10.1016/j.critrevonc.2016.11.017. Epub 2016 Dec 1.
Expressions of many microRNAs (miRNAs) in response to ionizing radiation (IR) have already been investigated and some of them seem to play an important role in the tumor radioresistance, normal tissue radiotoxicity or as predictive biomarkers to radiation. miR-34a is an emerging miRNA in recent radiobiology studies. Here, we review this miR-34 family member by detailing its different roles in radiation response and we will discuss about the role that it can play in radiation treatment. Thus, we will show that IR regulates miR-34a by increasing its expression. We will also highlight different biological processes involved in cellular response to IR and regulated by miR-34a in order to demonstrate the role it can play in tumor radio-response or normal tissue radiotoxicity as a radiosensitizer or radioprotector. miR-34a is poised to assert itself as an important player in radiobiology and should become more and more important in radiation therapy management.
许多微小RNA（miRNA）对电离辐射（IR）的反应表达已经得到研究，其中一些似乎在肿瘤放射抗性、正常组织放射毒性或作为辐射预测生物标志物方面发挥重要作用。miR-34a是近期放射生物学研究中一个新兴的miRNA。在此，我们通过详细阐述其在辐射反应中的不同作用来综述这个miR-34家族成员，并讨论它在放射治疗中可能发挥的作用。因此，我们将表明IR通过增加其表达来调节miR-34a。我们还将强调细胞对IR反应中涉及的不同生物学过程以及由miR-34a调节的过程，以证明它作为放射增敏剂或放射保护剂在肿瘤放射反应或正常组织放射毒性中可能发挥的作用。miR-34a有望在放射生物学中确立其重要地位，并且在放射治疗管理中应该会变得越来越重要。
