Moro Angela M, Brucker Natália, Charão Mariele F, Baierle Marília, Sauer Elisa, Goethel Gabriela, Barth Anelise, Nascimento Sabrina N, Gauer Bruna, Durgante Juliano, Amaral Beatriz S, Neto Francisco R A, Gioda Adriana, Garcia Solange C
Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Specialized Faculty in the Health Area of Rio Grande do Sul (FASURGS), Passo Fundo, RS, Brazil.
Laboratory of Toxicology (LATOX), Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Mutat Res Genet Toxicol Environ Mutagen. 2017 Jan;813:1-9. doi: 10.1016/j.mrgentox.2016.11.002. Epub 2016 Nov 5.
Women are employed in increasing numbers as gasoline station attendants, a work category with risk of exposure to benzene. We have assessed the effect of gender on biomarkers of occupational benzene exposure. Gasoline station attendants (20 men and 20 women) and 40 control individuals (20 men and 20 women) with no history of occupational benzene exposure were evaluated. Benzene exposure was monitoring by environmental and biological measurements. Urinary trans,trans-muconic acid levels, well-known genetic and hematological alterations linked to benzene exposure, and non-cancer effects on the immune, hepatic, and renal systems were investigated. Our results suggest a potential effect of gender on some effects of occupational benzene exposure, particularly the hematological parameters and trans,trans-muconic acid levels. Despite limitations of our study, our findings provide important considerations about occupational exposure of women to benzene and may contribute to the development of occupational protection standards.
越来越多的女性受雇成为加油站工作人员，这是一个存在接触苯风险的工作类别。我们评估了性别对职业性苯接触生物标志物的影响。对加油站工作人员（20名男性和20名女性）以及40名无职业性苯接触史的对照个体（20名男性和20名女性）进行了评估。通过环境和生物测量来监测苯接触情况。研究了尿中反式，反式-粘康酸水平、与苯接触相关的著名遗传和血液学改变，以及对免疫、肝脏和肾脏系统的非癌症影响。我们的结果表明，性别可能对职业性苯接触的某些影响有作用，特别是血液学参数和反式，反式-粘康酸水平。尽管我们的研究存在局限性，但我们的发现为女性职业性接触苯提供了重要的考虑因素，并可能有助于制定职业防护标准。
