Grimm R J, Hemenway W G, Lebray P R, Black F O
Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, Oregon 97210.
Acta Otolaryngol Suppl. 1989;464:1-40. doi: 10.3109/00016488909138632.
Neurological and neuro-otological studies were carried out on 102 adults with mild cranio-cervical trauma productive of positional vertigo and perilymph fistula as confirmed by laboratory tests, and by the finding of perilymph fistula at tympanotomy in the surgically managed group. In this patient group, all other neurological and neuro-otological diagnoses were excluded, e.g. epilepsy, cerebral palsy, multiple sclerosis, retardation; and for the neuro-otological group those with a history of ototoxicity, labyrinthitis, Meniere's disease, chronic ear infections, or developmental or familial disorders. Emphasis in this study was on mild trauma: fewer than half of the sample had been rendered unconscious in the injury of record, and a third of the cases were of whiplash type, with no loss of consciousness (LOC) and no remembered headstrike. These concomitant lesions comprise the perilymph fistula syndrome (PLFS) with a unique profile of neurological, perceptual, and cognitive deficits resembling a post-concussion injury. A complete description of the clinical picture is given, including psychological, cognitive and diagnostic tests, and the outcome of bedrest vs. surgical management. PLFS can arise from minor trauma, fistula are frequently bilateral (71/102), a mild sensorineural hearing loss is of variable occurrence (53%), secondary hydrops is not uncommon, and women appear more vulnerable than men for developing the syndrome. As based upon combined laboratory techniques and clinical symptomology, fistula were correctly predicted in 61 of 65 laser-operated ears. The positional vertigo component of PLFS was in all cases managed according to a special physical therapy program utilizing exercises for vestibular symptom habituation. Even when diagnosed late, a good-to-excellent outcome was achieved in 70% of treated patients.
对102名患有轻度颅颈创伤的成年人进行了神经学和神经耳科学研究,这些创伤导致了位置性眩晕和外淋巴瘘,实验室检查以及手术治疗组中鼓膜切开术中发现外淋巴瘘均证实了这一点。在该患者组中,排除了所有其他神经学和神经耳科学诊断,例如癫痫、脑瘫、多发性硬化症、智力迟钝;对于神经耳科学组,排除了有耳毒性、迷路炎、梅尼埃病、慢性耳部感染或发育性或家族性疾病病史的患者。本研究的重点是轻度创伤:样本中不到一半的人在记录的损伤中失去意识,三分之一的病例为挥鞭样损伤,没有意识丧失(LOC)且没有头部撞击记忆。这些伴随病变构成了外淋巴瘘综合征(PLFS),其具有独特的神经学、感知和认知缺陷特征,类似于脑震荡后损伤。给出了临床表现的完整描述,包括心理、认知和诊断测试,以及卧床休息与手术治疗的结果。PLFS可由轻微创伤引起,瘘管通常为双侧(71/102),轻度感音神经性听力损失发生率不一(53%),继发性积水并不少见,女性似乎比男性更容易患该综合征。基于联合实验室技术和临床症状学,65只接受激光手术的耳朵中有61只正确预测出了瘘管。PLFS的位置性眩晕成分在所有病例中均根据一项特殊的物理治疗方案进行处理,该方案利用针对前庭症状适应的锻炼。即使诊断较晚,70%的接受治疗的患者仍取得了良好至极佳的结果。