Karlberg J
Department of Anatomy, University of Göteborg, Sweden.
Acta Paediatr Scand Suppl. 1989;350:70-94. doi: 10.1111/j.1651-2227.1989.tb11199.x.
A new approach to modelling the individual human linear growth curve from birth to maturity is presented in detail. The model, which is also suitable for other measurements, breaks down growth mathematically into three additive and partly superimposed components--Infancy, Childhood and Puberty (the ICP-model). A key feature of this approach is that these components of the human growth curve from birth to adulthood strongly reflect the different hormonal phases of the growth process. As a result, the model provides an improved instrument for detecting and understanding growth failure. The model also sheds light on some central facets of human growth. For instance, the dramatic change in body proportions during the first years of life is found to be related to an enhanced influence of the Childhood component on the legs as compared with the trunk. The size of the Puberty component is shown to be time-invariant and to be superimposed on the decelerating Childhood component during adolescence. Early pubertal maturation is known to give a higher peak velocity than late maturation, so this variation in pubertal gain must be explained by the shape of the Childhood component alone.
本文详细介绍了一种从出生到成熟阶段对个体人类线性生长曲线进行建模的新方法。该模型同样适用于其他测量，它将生长在数学上分解为三个相加且部分重叠的成分——婴儿期、儿童期和青春期（ICP模型）。这种方法的一个关键特征是，从出生到成年的人类生长曲线的这些成分强烈反映了生长过程中不同的激素阶段。因此，该模型为检测和理解生长发育迟缓提供了一种更有效的工具。该模型还揭示了人类生长的一些核心方面。例如，人们发现生命最初几年身体比例的巨大变化与儿童期成分对腿部的影响相对于躯干增强有关。青春期成分的大小被证明是时间不变的，并在青春期叠加在减速的儿童期成分上。已知青春期早熟比晚熟具有更高的峰值速度，因此青春期增长的这种差异必须仅由儿童期成分的形状来解释。
