Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600717. Epub 2017 Feb 7.
The aim of the current study was to investigate the effect of sesamol, a natural powerful antioxidant and anti-inflammatory phenol derivative of sesame oil, on adiposity and adiposity-related metabolic disturbances in mice fed with western diet, and the potential underlying mechanisms focusing on the mitochondria-lipid metabolism.
In the experimental model that consisted of 3-month-old C57BL/6J mice divided into three groups with/without sesamol in the drinking water including standard diet, high fat and high fructose diet (HFFD), and HFFD with sesamol. Results demonstrated that sesamol mitigated bodyweight gain, development of insulin resistance induced by HFFD. Sesamol was found partially normalized serum and hepatic lipid contents, as well as suppressed HFFD-induced lipogenesis in liver via regulating mitochondria-related triglyceride/cholesterol metabolism genes expressions. Importantly, sesamol decreased mass and adipocyte sizes of white adipose tissues and brown adipose tissues by improving mitochondria-related genes expressions including Pgc1a and Ucp1. Moreover, sesamol was also found to reduce differentiation and mitochondrial metabolic inhibitors (oligomycin and antimycin A) stimulated lipid accumulation in 3T3-L1 adipocytes.
Taken together, this study provides compelling evidence that sesamol supplementation reduced adipocyte size and adipogenesis of diet-induced obesity by regulating mitochondria lipid metabolism.
本研究旨在探讨芝麻油中天然强效抗氧化剂和抗炎酚类衍生物芝麻酚对高脂肪高果糖饮食喂养的小鼠肥胖及其相关代谢紊乱的影响，并重点探讨其潜在的机制，即聚焦在线粒体-脂质代谢。
在实验模型中，将 3 个月大的 C57BL/6J 小鼠分为三组，分别为饮水含标准饮食、高脂肪高果糖饮食（HFFD）和 HFFD 加芝麻酚的对照组、HFFD 组和 HFFD 加芝麻酚组。结果表明，芝麻酚减轻了 HFFD 诱导的体重增加和胰岛素抵抗。芝麻酚部分纠正了血清和肝脏脂质含量，并通过调节与线粒体相关的甘油三酯/胆固醇代谢基因的表达，抑制了 HFFD 诱导的肝脏脂肪生成。重要的是，芝麻酚通过改善与线粒体相关的基因表达（包括 Pgc1a 和 Ucp1），减少了白色和棕色脂肪组织的质量和脂肪细胞大小。此外，芝麻酚还被发现可减少分化和线粒体代谢抑制剂（寡霉素和抗霉素 A）刺激的 3T3-L1 脂肪细胞中的脂质积累。
综上所述，本研究提供了令人信服的证据，表明芝麻酚补充剂通过调节线粒体脂质代谢，减少了饮食诱导肥胖的脂肪细胞大小和脂肪生成。
