Chan Jessica L, Wang Erica T
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Gynecol Oncol. 2017 Mar;144(3):631-636. doi: 10.1016/j.ygyno.2016.12.013. Epub 2016 Dec 21.
The emerging field of oncofertility addresses fertility and the reproductive health needs for cancer patients, a key topic in cancer survivorship. Given that the standard treatment for gynecologic malignancies involves removal of reproductive organs, pelvic radiation, or chemotherapy, the effect of such treatment on fertility and options for fertility preservation are even more relevant than for other malignancies. In young women with new diagnoses of cervical, endometrial, or ovarian cancers, viable strategies for fertility preservation without compromising oncological outcome exist and should be considered. We present here a comprehensive review of the literature as it pertains to gynecologic malignancies on 1) the effects of radiation and chemotherapy on fertility, 2) fertility-sparing surgeries and the role of assisted reproductive technology, and 3) fertility preservation in adolescent girls and women with BRCA germline mutations.
肿瘤生育学这一新兴领域关注癌症患者的生育能力及生殖健康需求，这是癌症幸存者中的一个关键话题。鉴于妇科恶性肿瘤的标准治疗方法包括切除生殖器官、盆腔放疗或化疗，这种治疗对生育能力的影响以及生育力保存的选择比其他恶性肿瘤更为重要。对于新诊断为宫颈癌、子宫内膜癌或卵巢癌的年轻女性，存在在不影响肿瘤治疗结果的情况下保存生育能力的可行策略，应予以考虑。我们在此对有关妇科恶性肿瘤的文献进行全面综述，内容涉及：1）放疗和化疗对生育能力的影响；2）保留生育功能的手术及辅助生殖技术的作用；3）携带BRCA种系突变的青春期女孩和女性的生育力保存。
