Staite N D, Cutshaw L G, Dunn C J
Department of Hypersensitivity Diseases Research, Upjohn Company, Kalamazoo, MI 49001.
Agents Actions. 1989 Jun;27(3-4):338-40. doi: 10.1007/BF01972816.
Three different immunization protocols were studied for their effect on methylated bovine serum albumin (mBSA)-induced arthritis. Mice were immunized with mBSA in Freund's incomplete adjuvant containing dextran and challenged 3 weeks later with antigen in one knee. After 7-14 days a strong inflammatory reaction developed without significant erosions of articular cartilage or bone. The reaction resolved between 28 and 35 days. In contrast, mice immunized with mBSA and complete Freund's adjuvant (CFA) developed inflammation that was accompanied by erosive disease. However, this pathology also resolved after 28-35 days. Mice immunized with mBSA in modified CFA developed inflammation and co-incident erosive disease that persisted for 60 days. Thus, three distinct arthropathies can be evoked depending on the immunization protocol employed.
研究了三种不同的免疫方案对甲基化牛血清白蛋白（mBSA）诱导的关节炎的影响。将小鼠用含有葡聚糖的弗氏不完全佐剂中的mBSA进行免疫，并在3周后用抗原攻击一侧膝关节。7-14天后出现强烈的炎症反应，关节软骨或骨无明显侵蚀。反应在28至35天之间消退。相比之下，用mBSA和完全弗氏佐剂（CFA）免疫的小鼠出现伴有侵蚀性疾病的炎症。然而，这种病理变化在28-35天后也会消退。用改良CFA中的mBSA免疫的小鼠出现炎症和同时发生的侵蚀性疾病，持续60天。因此，根据所采用的免疫方案，可以诱发三种不同的关节病。
